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Clinical Research on efficacy of Hydration and Statins in Preventing Contrast-induced Nephropathy.
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- Author:
- No author available
- Journal Title:
- PREVENTION AND TREATMENT OF CARDIO-CEREBRAL-VASCULAR DISEASE
- Issue:
- 1
- DOI:
- 10.3969/j.issn.1009-816X.2013.01.05
- Key Word:
- 水化;他汀类药物;对比剂肾病;预防
Abstract： 目的 探讨他汀类药物在预防对比剂肾病(contrast-induced nephropathy,CIN)中的作用.方法 选择行经皮冠状动脉造影病人115例,采用随机数字表法将病人分为他汀组(n=40)、水化组(n=34)以及对照组(n=41).他汀组于冠状动脉造影术前3d开始每晚顿服阿托伐他汀20mg,水化组予0.9%氯化钠注射液静脉滴注,速度为1ml/(kg·h),一般于术前4h开始至术后12h结束,对照组未服用阿托伐他汀及其他调脂类药物亦未应用水化处理.观察患者术前1d、术后36～48h血清肌酐(Scr)、内生肌酐清除率(Ccr)、尿白蛋白肌酐比(UACR)以及超敏C反应蛋白(hsCRP)的改变情况.结果 他汀组及对照组两组患者术后血hsCRP、Scr,UACR较术前均升高(均P<0.05),而血Ccr较术前降低(P<0.05).对照组患者术后血hsCRP、UACR较他汀组术后明显升高(P<0.05),对照组对比剂肾病发生率(9.76%)高于他汀组(5.00%).水化组术后血hsCRP、Scr、UACR及血Ccr与术前相比差异无统计学意义,对比剂肾病发生率明显小于他汀组及对照组.结论 造影剂可造成轻微的肾功能损害;术前3d使用他汀药物,可能具有减轻炎症反应、预防造影剂肾病发生的作用,但相比之下水化处理更能明显减少对比剂肾病的发生.
- [1]周霞,金元哲,王琦,等.大剂量阿托伐他汀预防对比剂肾病[J].2009,(5).
- [2]Khamaisi M,Rosenberger C,Rosen S,etc.Reactive oxygen species and the pathogenesis of radiocontrast-induced nephropathy.[J].2010,45(4).
- [3]Melfi R,Patti G,Nusca A,etc.Statins and their role in pre-percutaneous coronary intervention.[J].2010,12(4).
- [4]Xinwei J,Jing Z,Xianghua F.Comparison of usefulness of simvastatin 20 mg versus 80 mg in preventing contrast-induced nephropathy in patients with acute coronary syndrome undergoing percutaneous coronary intervention.[J].2009,104(4).
- [5]Attallah N,Yassine L,Yee J,etc.The potential role of statins in contrast nephropathy.[J].2004,62(4).
- [6]Zubelewicz-Szkodzinska,B.,Lekston,A.,Romanowski,W.,etc.Serum interleukin-6 concentration predicts contrast-induced nephropathy in patients undergoing percutaneous coronary intervention[J].2010,21(2).
- [7]James, Tumlin,Fulvio, Stacul,Andy, Adam,etc.Pathophysiology of contrast-induced nephropathy.[J].2006,98(6A).