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The Effect of Philippinarum Ruditapes Diet on Atherosclerosis in Rabbits
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- Author:
- No author available
- Journal Title:
- PREVENTION AND TREATMENT OF CARDIO-CEREBRAL-VASCULAR DISEASE
- Issue:
- 1
- DOI:
- 10.3969/j.issn.1009-816X.2003.01.010
- Key Word:
- 菲律宾蛤仔;动脉粥样硬化;动物模型;内膜/中膜厚度比值
Abstract： 目的观察菲律宾蛤仔饮食对兔动脉粥样硬化的影响.方法 80只新西兰白兔随机平均分为四组.A组给普通饮食,B、C组前6周给高脂饮食,后8周B组给菲律宾蛤仔饮食,C组改为普通饮食(即洗脱期),D组给高脂饮食,共喂食14周.6周末每组动物随机处死一半,其余动物于14周末处死.所有动物每2周采血一次,检测TC、HDL-C、LDL-C和LDL-C/HDL-C.6周末和14周末,观察主动脉粥样硬化病理变化;计算主动脉内膜/中膜(I/M)厚度比值.结果 (1)6周末,B、C、D三组均成功建立兔动脉粥样硬化模型;(2)14周末,B组HDL-C浓度显著高于C组(P＜0.05),B组LDL-C/HDL-C显著低于C组(P＜0.05);(3)14周末B组I/M厚度比值显著大于6周末(P＜0.05);(5)洗脱期B组HDL-C下降幅度小于C组,B组LDL-C/HDL-C下降幅度大于C组.结论在兔动脉粥样硬化模型形成后的洗脱期,给予菲律宾蛤仔饮食可减慢血清HDL-C浓度的下降,对HDL-C有保护作用.
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