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Effect ofTAC Neoadjuvant Chemotherapy Combined with Surgical Resection on the Prognosis of Locally Advanced Breast Cancer
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- Author:
- No author available
- Journal Title:
- Journal of Military Surgeon in in Southwest China
- Issue:
- 2
- DOI:
- 10.3969/j.issn.1672-7193.2018.02.011
- Key Word:
- TAC方案;新辅助化疗;手术;局部晚期乳腺癌
Abstract： 目的 探讨TAC方案新辅助化疗联合手术治疗对局部晚期乳腺癌预后的影响.方法 以56例局部晚期乳腺癌患者作为研究对象,根据治疗方式的不同分为观察组和对照组,各28例.观察组予以TAC方案新辅助化疗联合手术治疗,术后继续同方案化疗直至疗程结束;对照组先行手术治疗,术后TAC方案化疗.分析观察组新辅助化疗治疗疗效,并比较两组手术治疗效果、2年无病生存率、局部复发率、远处转移率及不良反应等.结果 观察组新辅助化疗有效率67.9％,疾病控制率为96.4％.两组患者手术治疗效果、局部复发率、远处转移率及化疗副反应无明显差异,结果无统计学意义(P>0.05).观察组2年无病生存率高于对照组,差异有统计学意义(P<0.05).结论 术前采用tAC方案新辅助化疗,能使大部分局部晚期乳腺癌患者肿瘤体积缩小,达到降期的目的,使手术难度降低,且能提高患者2年无病生存率.其不良反应发生率与术后辅助化疗无明显差异,治疗的耐受性好,值得临床推广运用.
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