Abstract： Objective To observe the clinical effect of katamine plus dexedetomidine in the anesthesia of pediatric surgery. Methods 120 children of ASA I to II (none for skull-opening, thoracic or abdominal surgery) were selected and divided into 2 groups:group I (n=90) and group II (n=30);drug administration started 1 minute before skin disinfection:intravenous injection of katamine (3mg/kg) and intravenous pumping of dexemedetomidine (1μg/kg·h) were made to cases in group I while intravenous of katamine (3mg/kg) and intra-venous pumping of saline were made to cases in group II;katamine (3mg/kg) was added to cases in both groups if body movement re-sponse was observed;dosage of total katamine, vital signs, recovery time and postoperative sedation scores were recorded and the anes-thetic effects in the 2 groups were compared. Results There existed no statistic difference in the general data, operation time and opera-tion scope between the 2 groups;the dosage of katamine in group I was obviously less and the vital signs of the cases were stable;the heart beat and blood pressure of the cases in group II at each time point increased significantly;there existed no obvious difference in re-covery time between the 2 groups;the cases in group I were more sedative and the cases number of satisfactory sedation scores were much bigger than that in group II, and there were less cases with body movement response in recovery time. Conclusions Katamine plus dexemedetomidine is of good anesthetic effect in pediatric surgery, which produces good analgesic and sedative effect and can ob-viously decrease the side effect in respiratory circulation by pure application of katamine and the occurrence of postoperative body movement response.