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Study of the Relativity between MVD and Histopathological Grade and Recurrence in Transitional Cell Carcinoma of Bladder
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- Author:
- No author available
- Journal Title:
- JOURNAL OF MILITARY SURGEON IN SOUTHWEST CHINA
- Issue:
- 6
- DOI:
- 10.3969/j.issn.1672-7193.2004.06.001
- Key Word:
- 膀胱肿瘤;血管形成;碱性成纤维细胞生长因子
Abstract： 目的观察膀胱癌微血管密度(MVD)及碱性成纤维细胞生长因子(bFCF)与膀胱癌分级及复发的关系.方法本组膀胱移行细胞癌患者62例,年龄36～82岁,平均65岁.采用免疫组织化学染色CD34观察膀胱癌组织中MVD以及bFGF的表达情况.结果G1级、G2级、G3膀胱癌中bFGF阳性率分别为33.3%、48%、73.7%,其中,G1级与G3级膀胱癌间差异有统计学意义(P＜0.05).膀胱癌复发组及未复发组bFGF阳性率分别为73.1%、36.1%(P＜0.05).G1级、G2级、G3膀胱癌MDV分别为44.3±11.6、53.5±10.6、71.9±15.3,G1级与G3级膀胱癌间差异有统计学意义(P＜0.05).膀胱癌复发组及未复发组MDV分别为41.7±10.9、77.2±15.3(P＜0.05).结论膀胱癌bFGF表达及MVD与其分级及肿瘤复发相关,MVD对膀胱癌复发有预测值.
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