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Fibroblast growth factor 21 plays a protective role in cardiovascular diseases by inducing autophagy

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Author:: No author available

Journal Title:: Acta Physiologica Sinica

Issue:: 4

DOI:: 10.13294/j.aps.2022.0061

Key Word:: 成纤维细胞生长因子21;自噬;心血管疾病

Abstract：成纤维细胞生长因子21(fibroblast growth factor 21,FGF21)是成纤维细胞生长因子家族中一个具有内分泌性质的生长因子.既往报道显示,FGF21参与能量代谢的调节过程,并在冠状动脉粥样硬化性心脏病、糖尿病、非酒精性脂肪肝病等心血管相关疾病中具有保护作用.新近研究发现,FGF21在多种组织和器官中可诱导自噬,而自噬参与了包括血管钙化、动脉粥样硬化、心肌缺血/再灌注损伤在内的多种心血管疾病的病理过程.因此,有学者推测FGF21可能通过调控自噬在多种心血管相关疾病中发挥保护作用.本文就FGF21通过诱导自噬在心血管疾病中发挥保护作用的相关研究进展作一综述.

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