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Progress in replicative senescence of mesenchymal stem cells regulated by micro-environment

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Author:: No author available

Journal Title:: Acta Physiologica Sinica

Issue:: 3

DOI:: 10.13294/j.aps.2022.0050

Key Word:: 间充质干细胞;复制性衰老;微环境

Abstract：间充质干细胞(mesenchymal stem cells,MSCs)是一类能自我更新和分化的多能细胞.越来越多的证据表明,MSCs在再生医学和组织工程等领域具有重要的作用.但是值得注意的是,与很多细胞一样,MSCs在长期体外扩增过程中会逐渐衰老,出现迁徙能力减弱、增殖速度减慢和分化潜能下降等干性减退的现象,这极大地阻碍了MSCs的应用.目前公认的引起MSCs复制性衰老的因素之一就是细胞生长的微环境.新近研究显示,外源性给药、氧浓度调节、细胞外基质(extracellular matrix,ECM)构建等最新技术都可以通过模拟或者调控微环境来改善干细胞的行为,延缓干细胞复制性衰老.本文首先综述了近年来关于MSCs复制性衰老特征和分子机制方面的研究进展,然后总结了通过改变微环境来保持MSCs干性的技术和方法,旨在为未来MSCs制剂大规模应用于组织工程和临床研究提供参考.

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