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Dynamic characteristics of brain networks in patients with irritable bowel syndrome based on functional magnetic resonance imaging

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Author:: No author available

Journal Title:: Acta Physiologica Sinica

Issue:: 3

DOI:: 10.13294/j.aps.2021.0033

Key Word:: 功能磁共振成像;大脑;功能连接;动态特性;肠易激综合征

Abstract：脑-肠互动紊乱是肠易激综合征(irritable bowel syndrome,IBS)发病的重要原因,但其脑功能动态特性仍不清楚.本研究针对以往基于功能磁共振成像的脑网络动态分析的缺点,提出一种基于逐时间点斜率分析的动态特性度量方法,以此来检测IBS患者脑功能动态异常变化情况.结果表明,与健康被试相比,IBS患者脑活动及功能连接均发生一定程度的改变.在经过FDR(false discovery rate)校正之后,只有右侧后扣带-左侧额中回、右侧后扣带-左侧苍白球这两条功能连接上表现出显著的动态特性异常,该结果与IBS患者的静态特性存在较大差异.以上结果为阐明IBS异常的机制提供了互补信息,可为IBS中枢靶点的揭示提供新的方向.

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