Paper - WANFANG MED ONLINE

You Position: Home > Paper

Role of endoplasmic reticulum stress response in regulation of adipose tissue metabolism

( views:6, downloads:0 )

Author:: No author available

Journal Title:: Acta Physiologica Sinica

Issue:: 1

DOI:: 10.13294/j.aps.2021.0005

Key Word:: 内质网应激;未折叠蛋白响应;脂肪组织;代谢炎症;肥胖

Abstract：在真核细胞中,内质网是蛋白合成、加工及质量监控的关键细胞器,也是Ca2+储存及脂质合成的重要场所.细胞通过未折叠蛋白响应(unfolded protein response,UPR)感应外界不同刺激引发的内质网应激,在维持细胞功能稳态中发挥至关重要的作用.在哺乳动物中,三个位于内质网的跨膜蛋白——肌醇依赖酶la(inositol-requiring enzyme la,IREla)、PKR样内质网激酶(PKR-like endoplasmic reticulum kinase,PERK)和活化转录因子6(activating transcription factor 6,ATF6)能够感应内质网腔内未折叠蛋白或错误折叠蛋白的积累,协同介导三条经典的UPR信号通路,通过促进下游靶基因的表达恢复内质网的蛋白折叠能力.近期大量研究表明,UPR参与细胞代谢与能量平衡的精细调节过程.脂肪组织是机体能量储存与消耗的关键场所,通过分泌多种脂肪因子调节机体的能量平衡和糖脂代谢;而在营养过剩状态下,多种内在因素和外部环境相互作用导致脂肪组织发生代谢炎症和功能异常,尤其是脂肪组织中的内质网应激响应与脂肪组织的功能紊乱密切相关,在肥胖和2型糖尿病等代谢疾病的发生和发展中发挥重要的作用.本综述旨在总结近年来有关UPR通路调节脂肪组织功能稳态方面的重要进展,探讨内质网应激响应与脂肪组织代谢紊乱的机制关联,以期促进我们深入了解肥胖及其相关代谢疾病的病理生理学基础.

Reference

[1]Carmela Sidrauski,Peter Walter.The Transmembrane Kinase Ire1p Is a Site-Specific Endonuclease That Initiates mRNA Splicing in the Unfolded Protein Response[J].1997,90(6).
[2]Shamu CE,Walter P.Oligomerization and Phosphorylation of the Ire1p Kinase During Intracellular Signaling from the Endoplasmic Reticulum to the Nucleus[J].1996,15(12).
[3]Duan X,Song W,Merali S,etc.Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals.[J].2008,57(9).
[4]Bo, Shan,Xiaoxia, Wang,Ying, Wu,etc.The metabolic ER stress sensor IRE1α suppresses alternative activation of macrophages and impairs energy expenditure in obesity.[J].2017,18(5).
[5]Rosen ED,Spiegelman BM.Adipocytes as regulators of energy balance and glucose homeostasis[J].2006,444(7121).
[6]Lowe,C.E.,Dennis,R.J.,Obi,U.,etc.Investigating the involvement of the ATF6α pathway of the unfolded protein response in adipogenesis[J].2012,36(9).
[7]Shirin Doroudgar,Christopher C Glembotski.ATF6 and thrombospondin 4 the dynamic duo of the adaptive endoplasmic reticulum stress response.[J].2013,112(1).
[8]Bobrovnikova-Marjon, E,Hatzivassiliou, G,Grigoriadou, C,etc.PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation[J].2008,105(42).
[9]Trayhurn P.Endocrine and signalling role of adipose tissue: new perspectives on fat.[J].2005,184(4).
[10]Kern PA,Sharma NK,Yao-Borengasser A,etc.Endoplasmic reticulum stress markers are associated with obesity in nondiabetic subjects.[J].2008,93(11).
[11]Stella, Liong,Martha, Lappas.Endoplasmic reticulum stress is increased in adipose tissue of women with gestational diabetes.[J].2015,10(4).
[12]S, Cinti.Adipose tissues and obesity.[J].1900,104(2).
[13]Elabd C,Chiellini C,Carmona.Human multipotent adipose-derived stem cells differentiate into functional brown adipocytes.[J].2009,27(11).
[14]Shijia,Huang,Yuying,Xing,Yong,Liu.Emerging roles for the ER stress sensor IRE1α in metabolic regulation and disease.[J].2019,294(49).
[15]Khoa D. Nguyen,Yifu Qiu,Xiaojin Cui,etc.Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis[J].2011,480(Dec.1 TN.7375).
[16]Tiziana Ronti,Graziana Lupattelli,Elmo Mannarino.The endocrine function of adipose tissue: an update[J].2006,64(4).
[17]Qian Guo,Sanli Jin,Hailong Hu,etc.Hypoxia in 3T3-L1 adipocytes suppresses adiponectin expression via the PERK and IRE1 unfolded protein response[J].2017,493(1).
[18]Cinti S.The adipose organ.[J].2005,73(1).
[19]Vaillancourt E,Smith RO,Furuhashi M,etc.Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes.[J].2006,313(5790).
[20]Grant,R.,Nguyen,K.Y.,Ravussin,A.,etc.Inactivation of C/ebp homologous protein-driven immune-metabolic interactions exacerbate obesity and adipose tissue leukocytosis[J].2014,289(20).
[21]Wang, Wenshan,Seale, Patrick.Control of brown and beige fat development[J].2016,17(11).
[22]Kajimura, Shingo,Sponton, Carlos Henrique.Multifaceted Roles of Beige Fat in Energy Homeostasis Beyond UCP1[J].2018,159(7).
[23]Witze, Eric S.,Riese, Matthew J.,Koretzky, Gary A.,etc.PERK Utilizes Intrinsic Lipid Kinase Activity To Generate Phosphatidic Acid, Mediate Akt Activation, and Promote Adipocyte Differentiation[J].2012,32(12).
[24]Hetz, Claudio,Papa, Feroz R..The Unfolded Protein Response and Cell Fate Control[J].2018,69(2).
[25]Yuliana, Ana,Daijo, Asumi,Jheng, Huei-Fen,etc.Endoplasmic Reticulum Stress Impaired Uncoupling Protein 1 Expression via the Suppression of Peroxisome Proliferator-Activated Receptor Binding Activity in Mice Beige Adipocytes.[J].2019,20(2).
[26]Matthew D, Shoulders,Lisa M, Ryno,Joseph C, Genereux,etc.Stress-independent activation of XBP1s and/or ATF6 reveals three functionally diverse ER proteostasis environments.[J].2013,3(4).
[27]Umut, Ozcan,Qiong, Cao,Erkan, Yilmaz,etc.Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes.[J].2004,306(5695).
[28]Rie, Asada,Soshi, Kanemoto,Koji, Matsuhisa,etc.IRE1α-XBP1 is a novel branch in the transcriptional regulation of Ucp1 in brown adipocytes.[J].2015,5.
[29]Yuzhong, Xiao,Tingting, Xia,Junjie, Yu,etc.Knockout of inositol-requiring enzyme 1α in pro-opiomelanocortin neurons decreases fat mass via increasing energy expenditure.[J].2016.
[30]Sha,H.,Yang,L.,Liu,M.,etc.Adipocyte spliced form of x-box-binding protein 1 promotes adiponectin multimerization and systemic glucose homeostasis[J].2014,63(3).
[31]Yingfeng, Deng,Zhao V, Wang,Ruth, Gordillo,etc.Adipocyte Xbp1s overexpression drives uridine production and reduces obesity.[J].2018,(Spec ).
[32]Maurel, M.,Chevet, E.,Tavernier, J.,etc.Getting RIDD of RNA: IRE1 in cell fate regulation[J].2014,39(5).
[33]Heather P. Harding,Yuhong Zhang,Huiquing Zeng,etc.An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress[J].2003,11(3).
[34]Welihinda AA,Kaufman RJ.The unfolded protein response pathway in Saccharomyces cerevisiae. Oligomerization and trans-phosphorylation of Ire1p (Ern1p) are required for kinase activation.[J].1996,271(30).
[35]Margaret F. Gregor,Emily S. Misch,Ling Yang,etc.The Role of Adipocyte\{XBP1\} in Metabolic Regulation during Lactation[J].2013,3(5).
[36]Saltiel, Alan R.,Olefsky, Jerrold M..Inflammatory mechanisms linking obesity and metabolic disease[J].2017,127(1).
[37]Ye J,Rawson RB,Komuro R,etc.ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs.[J].2000,6(6).
[38]Wang Yan,Dai Jianli,Liu Yong,etc.Dual role for inositol-requiring enzyme 1α in promoting the development of hepatocellular carcinoma during diet-induced obesity in mice[J].2018,68(2).
[39]Wang, Miao,Kaufman, Randal J..Protein misfolding in the endoplasmic reticulum as a conduit to human disease[J].2016,529(Jan.21 TN.7586).
[40]Roumans, Nadia J. T.,Camps, Stefan G.,Renes, Johan,etc.Weight loss-induced stress in subcutaneous adipose tissue is related to weight regain[J].2016,115(5).
[41]Matthew Harms,Patrick Seale.Brown and beige fat: development, function and therapeutic potential.[J].2013,19(10).
[42]Fabbrini E,Hotamisligil GS,Gregor MF,etc.Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss.[J].2009,58(3).
[43]Chen H,He Y,Sha H.The IRE1alpha-XBP1 pathway of the unfolded protein response is required for adipogenesis.[J].2009,9(6).
[44]Gokhan S. Hotamisligil.Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease[J].2010,140(6).
[45]Peter Walter,David Ron.The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation[J].2011,334(Nov.25 TN.6059).
[46]Schindler, AJ,Schekman, R.In vitro reconstitution of ER-stress induced ATF6 transport in COPII vesicles[J].2009,106(42).
[47]Han,J.,Malhi,H.,Kaufman,R.J.,etc.ER stress signalling through eIF2α and CHOP, but not IRE1α, attenuates adipogenesis in mice[J].2013,56(4).
[48]McGee K,Schisano B,Alhusaini S,etc.Lipopolysaccharide, high glucose and saturated fatty acids induce endoplasmic reticulum stress in cultured primary human adipocytes: Salicylate alleviates this stress.[J].2010,397(3).
[49]Deng, Yingfeng,Wang, Zhao V.,Gordillo, Ruth,etc.An adipo-biliary-uridine axis that regulates energy homeostasis[J].2017,355(Mar.17 TN.6330).
[50]Walter P,Ron D.Signal integration in the endoplasmic reticulum unfolded protein response[J].2007,8(7).
[51]Jiang,S.,Yan,C.,Fang,Q.-C.,etc.Fibroblast growth factor 21 is regulated by the IRE1α-XBP1 branch of the unfolded protein response and counteracts endoplasmic reticulum stress-induced hepatic steatosis[J].2014,289(43).
[52]Evan D. Rosen,Bruce M. Spiegelman.What We Talk About When We Talk About Fat[J].2014,156(1/2).
[53]Ferrante, A. W..The immune cells in adipose tissue[J].2013,15(3).
[54]Camargo, A,Meneses, M. E,Rangel-Zuniga, O. A,etc.Endoplasmic reticulum stress in adipose tissue determines postprandial lipoprotein metabolism in metabolic syndrome patients.[J].2013,57(12).
[55]K, Haze,H, Yoshida,H, Yanagi,etc.Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress.[J].1999,10(11).
[56]Kaufman RJ.The Mammalian Unfolded Protein Response.[J].2005,74.
[57]Ting, Mao,Mengle, Shao,Yifu, Qiu,etc.PKA phosphorylation couples hepatic inositol-requiring enzyme 1alpha to glucagon signaling in glucose metabolism.[J].2011,108(38).
[58]Yifu, Qiu,Ting, Mao,Yongliang, Zhang,etc.A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cells.[J].2010,3(106).
[59]Mengle, Shao,Bo, Shan,Yang, Liu,etc.Hepatic IRE1α regulates fasting-induced metabolic adaptive programs through the XBP1s-PPARα axis signalling.[J].2014,5.
[60]Walden TB,Petrovic N,Shabalina I.Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocyt[J].2010,285(10).
[61]Gregor MF,Hotamisligil GS.Thematic review series: Adipocyte Biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease.[J].2007,48(9).
[62]Boden,G.,Cheung,P.,Kresge,K.,etc.Insulin resistance is associated with diminished endoplasmic reticulum stress responses in adipose tissue of healthy and diabetic subjects[J].2014,63(9).
[63]Zelechowska, P.,Agier, J.,Kozlowska, E.,etc.Mast cells participate in chronic low-grade inflammation within adipose tissue[J].2018,19(5).
[64]Boden,G.,Cheung,P.,Salehi,S.,etc.Insulin regulates the unfolded protein response in human adipose tissue[J].2014,63(3).
[65]Didier F, Pisani,Mansour, Djedaini,Guillaume E, Beranger,etc.Differentiation of Human Adipose-Derived Stem Cells into "Brite" (Brown-in-White) Adipocytes.[J].2011,2.
[66]Saverio, Cinti.Between brown and white: novel aspects of adipocyte differentiation.[J].2011,43(2).