Paper - WANFANG MED ONLINE

You Position: Home > Paper

Source, metabolism and function of dopamine in digestive tract

( views:177, downloads:0 )

Author:: No author available

Journal Title:: Acta Physiologica Sinica

Issue:: 3

DOI:: 10.13294/j.aps.2020.0036

Key Word:: 消化道;多巴胺;单胺氧化酶;儿茶酚-O-甲基转移酶

Abstract：多巴胺(dopamine,DA)是一种广泛存在于中枢神经系统和外周组织的儿茶酚胺类神经递质,其功能越来越受到学者们的关注,尤其是近年发现DA可以调节免疫系统功能,DA与肠黏膜炎症相关疾病联系的研究成为热点.消化道是外周DA的重要来源,DA不仅产生于肠神经系统和消化道上皮等部位,而且还大量产自于肠道微生物.机体组织中DA的含量变化除了受其合成酶影响外,还受到两个重要的代谢酶——单胺氧化酶(monoamine oxidase,MAO)和儿茶酚-O-甲基转移酶(catechol-O-methyltransferase,COMT)的调控.本文主要对消化道DA的来源和功能、DA代谢酶的分布和功能进行综述.

Reference

[1]Billett, E. E..Monoamine Oxidase (MAO) in Human Peripheral Tissues[J].2004,25(1).
[2]Erkki Nissinen,Raimo Tuominen,Vesa Perhoniemi,etc.Catechol-O-methyltransferase activity in human and rat small intestine[J].1988,42(25).
[3]Jackson Lewis V,Smeyne RJ.The MPTP model of Parkinson's disease.[J].2005,134(1).
[4]Quevrain, E.,Maubert, M. A.,Michon, C.,etc.Identification of an anti-inflammatory protein from Faecalibacterium prausnitzii, a commensal bacterium deficient in Crohn's disease[J].2016,65(3).
[5]F. Magro,S. Fraga,T. Ribeiro,etc.Decreased availability of intestinal dopamine in transmural colitis may relate to inhibitory effects of interferon-<em><img src="http://onlinelibrarystatic.wiley.com/undisplayable_characters/0003b3.gif" alt="[gamma]"/></em> upon <span class="smallCaps">L<[J].2004,180(4).
[6]A Barcelo,J Claustre,F Moro,etc.Mucin secretion is modulated by luminal factors in the isolated vascularly perfused rat colon[J].2000,46(2).
[7]M K, Barry,J D, Aloisi,S P, Pickering,etc.Luminal adrenergic agents modulate ileal transport: discrimination between alpha 1 and alpha 2 receptors.[J].1994,167(1).
[8]Thomas Müller,Peter Riederer.Monoamine oxidase-B inhibitors in the treatment of Parkinson’s disease: clinical-pharmacological aspects[J].2018,125(11).
[9]T Karhunen,C Tilgmann,I Ulmanen,etc.Distribution of catechol-O-methyltransferase enzyme in rat tissues.[J].1994,42(8).
[10]Tolstanova, Ganna,Deng, Xiaoming,Ahluwalia, Amrita,etc.Role of Dopamine and D2 Dopamine Receptor in the Pathogenesis of Inflammatory Bowel Disease[J].2015,60(10).
[11]Yan, Yiqing,Jiang, Wei,Liu, Lei,etc.Dopamine Controls Systemic Inflammation through Inhibition of NLRP3 Inflammasome[J].2015,160(1/2).
[12]Natale G,Kastsiushenka O,Fulceri F,etc.MPTP-induced parkinsonism extends to a subclass of TH-positive neurons in the gut.[J].2010,1355.
[13]Basu S,Chakroborty D,Sarkar C,etc.Dopamine regulates endothelial progenitor cell mobilization from mouse bone marrow in tumor vascularization.[J].2008,118(4).
[14]Gershon MD,Li ZS,Chen JJ,etc.Enteric dopaminergic neurons: definition, developmental lineage, and effects of extrinsic denervation.[J].2004,24(6).
[15]Tolosa,E.,Stern,M.B..Efficacy, safety and tolerability of rasagiline as adjunctive therapy in elderly patients with Parkinson's disease[J].2012,19(2).
[16]N J, Christensen,O, Brandsborg.Dopamine in human gastric juice determined by a sensitive double-isotope-derivative technique.[J].1974,34(4).
[17]Jyothi K, Mallajosyula,Deepinder, Kaur,Shankar J, Chinta,etc.MAO-B elevation in mouse brain astrocytes results in Parkinson's pathology.[J].2008,3.
[18]Daniel,Villageliú,Mark,Lyte.Dopamine production in Enterococcus faecium: A microbial endocrinology-based mechanism for the selection of probiotics based on neurochemical-producing potential.[J].2018,13(11).
[19]Almeida L,Bonifacio MJ,Palma PN,etc.Catechol-O-methyltransferase and its inhibitors in Parkinson's disease.[J].2007,13(3).
[20]Xiaoli Zhang,Yun Li,Chenzhe Liu,etc.Alteration of enteric monoamines with monoamine receptors and colonic dysmotility in 6-hydroxydopamine-induced Parkinson's disease rats[J].2015,166(2).
[21]Ito A,Tani T,Arai R,etc.Immunocytochemical localization of monoamine oxidase type B in enterochromaffin-like cells of rat oxyntic mucosa.[J].2004,121(3).
[22]F. Magro,M.A. Vieira-Coelho,S. Fraga,etc.Impaired Synthesis or Cellular Storage of Norepinephrine, Dopamine, and 5-Hydroxytryptamine in Human Inflammatory Bowel Disease[J].2002,47(1).
[23]Jan Häggendal.The Presence of Dopamine in Human Gastric Juice[J].1967,71(1).
[24]Zhu JX,Guo H,Li XF,etc.Entacapone promotes cAMP-dependent colonic Cl(-) secretion in rats.[J].2011,23(7).
[25]Gibbons SJ,Farrugia G.The role of carbon monoxide in the gastrointestinal tract.[J].2004,556(Pt.2).
[26]Siddiqui A,Mallajosyula JK,Rane A,etc.Ability to delay neuropathological events associated with astrocytic MAO-B increase in a Parkinsonian mouse model: implications for early intervention on disease progression.[J].2011,43(2).
[27]Fox, S. H.,Katzenschlager, R.,Lim, S.,etc.International Parkinson and movement disorder society evidence-based medicine review: Update on treatments for the motor symptoms of Parkinson's disease (vol 33, pg 1248, 2018)[J].2018,33(12).
[28]Li,X.,Fan,R.,Zhang,Y.,etc.Dopamine receptor D 1 mediates the inhibition of dopamine on the distal colonic motility[J].2012,159(5).
[29]Vieira Coelho-MA,Teixeira VL,Soares da-Silva-P,etc.Caco-2 cells in culture synthesize and degrade dopamine and 5-hydroxytryptamine: a comparison with rat jejunal epithelial cells.[J].1999,64(1).
[30]Yard BA,Brinkkoetter P,Hanusch C,etc.Clinical review: immunomodulatory effects of dopamine in general inflammation.[J].2004,8(6).
[31]Brockington A,Moron JA,Rocha BA,etc.Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines.[J].2002,22(2).
[32]Rebecca Wall,John F. Cryan,R. Paul Ross,etc.Bacterial Neuroactlve Compounds Produced by. Psychobiotics[J].2014,817.
[33]Ulmanen I,Taskinen J,Tilgmann C,etc.Kinetics of human soluble and membrane-bound catechol O-methyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme.[J].1995,34(13).
[34]Marsala,S.Z.,Gioulis,M.,Tinazzi,M.,etc.A systematic review of catechol-o-methyltransferase inhibitors: Efficacy and safety in clinical practice[J].2012,35(4).
[35]David R P, Guay.Rasagiline (TVP-1012): a new selective monoamine oxidase inhibitor for Parkinson's disease.[J].2006,4(4).
[36]E A, Tsavkelova,I V, Botvinko,V S, Kudrin,etc.Detection of neurotransmitter amines in microorganisms with the use of high-performance liquid chromatography.[J].1900,372.
[37]A A, Akopian,M V, Arutiunian,A M, Agavelian.[The role of monoamine oxidase in large intestine pathology].[J].1900,40(6).
[38]Rouge Pont F,Usiello A,Gonon F,etc.Changes in extracellular dopamine induced by morphine and cocaine: crucial control by D2 receptors.[J].2002,22(8).
[39]G, Eisenhofer,A, Aneman,P, Friberg,etc.Substantial production of dopamine in the human gastrointestinal tract.[J].1997,82(11).
[40]Lipska BK,Hyde TM,Herman MM,etc.Catechol O-methyltransferase mRNA expression in human and rat brain: evidence for a role in cortical neuronal function.[J].2003,116(1).
[41]Li-Sheng Li,Chen-Zhe Liu,Jing-Dong Xu,etc.Effect of entacapone on colon motility and ion transport in a rat model of Parkinson's disease[J].2015,(12).
[42]Finberg,J.P.M..Update on the pharmacology of selective inhibitors of MAO-A and MAO-B: Focus on modulation of CNS monoamine neurotransmitter release[J].2014,143(2).
[43]Marina G. Smirnova,Li Guo,John P. Birchall,etc.LPS up-regulates mucin and cytokine mRNA expression and stimulates mucin and cytokine secretion in goblet cells[J].2003,221(1).
[44]Eliassi A,Aleali F,Ghasemi T.Peripheral dopamine D2-like receptors have a regulatory effect on carbachol-, histamine- and pentagastrin-stimulated gastric acid secretion.[J].2008,35(9).
[45]Masaaki Kawano,Rie Takagi,Atsushi Kaneko,etc.Berberine is a dopamine D1- and D2-like receptor antagonist and ameliorates experimentally induced colitis by suppressing innate and adaptive immune responses[J].2015,289.
[46]Wu, Yuanyuan,Zhen, Wenrui,Geng, Yanqiang,etc.Effects of dietary Enterococcus faecium NCIMB 11181 supplementation on growth performance and cellular and humoral immune responses in broiler chickens[J].2019,98(1).
[47]Manuel J. Rodríguez,Josep Saura,Ellen E. Billett,etc.Cellular localization of monoamine oxidase A and B in human tissues outside of the central nervous system[J].2001,304(2).
[48]Amit T,Weinreb O,Bar Am O,etc.Rasagiline: a novel anti-Parkinsonian monoamine oxidase-B inhibitor with neuroprotective activity.[J].2010,92(3).
[49]Michelangelo Auteri,Maria Grazia Zizzo,Antonella Amato,etc.Dopamine induces inhibitory effects on the circular muscle contractility of mouse distal colon via D1- and D2-like receptors[J].2016,(3).
[50]Sartor, R. Balfour,Wu, Gary D..Roles for Intestinal Bacteria, Viruses, and Fungi in Pathogenesis of Inflammatory Bowel Diseases and Therapeutic Approaches[J].2017,152(2).
[51]Eisenhofer G,Kopin IJ,Goldstein DS.Catecholamine metabolism: a contemporary view with implications for physiology and medicine.[J].2004,56(3).
[52]Fan, R. -F.,Feng, X. -Y.,Zhang, D. -N.,etc.Dopamine enhances duodenal epithelial permeability via the dopamine D-5 receptor in rodent[J].2017,220(1).
[53]Bartl,J.,Müller,T.,Grünblatt,E.,etc.Chronic monoamine oxidase-B inhibitor treatment blocks monoamine oxidase-A enzyme activity[J].2014,121(4).
[54]Ustione,A.,Piston,D.W..Dopamine synthesis and D3 receptor activation in pancreatic β-cells regulates insulin secretion and intracellular [Ca2 +] oscillations[J].2012,26(11).
[55]Tian YM,Chen X,Luo DZ,etc.Alteration of dopaminergic markers in gastrointestinal tract of different rodent models of Parkinson's disease.[J].2008,153(3).
[56]Parmar NS,Desai JK,Goyal RK.Characterization of dopamine receptor subtypes involved in experimentally induced gastric and duodenal ulcers in rats.[J].1999,51(2).
[57]Papa, Ilenia,Saliba, David,Ponzoni, Maurilio,etc.T-FH-derived dopamine accelerates productive synapses in germinal centres[J].2017,547(Jul.20 TN.7663).
[58]Cote M,Drouin Ouellet J,Cicchetti F,etc.The critical role of the MyD88-dependent pathway in non-CNS MPTP-mediated toxicity.[J].2011,25(6).
[59]Bortolato M,Chen K,Shih JC.Monoamine oxidase inactivation: from pathophysiology to therapeutics.[J].2008,60(13/14).
[60]Shih JC,Chen K.Regulation of MAO-A and MAO-B gene expression.[J].2004,11(15).
[61]Rosario Monteiro,Fatima Martel,Clara Lemos.Uptake of serotonin at the apical and basolateral membranes of human intestinal epithelial (caco-2) cells occurs through the neuronal serotonin transporter (SERT)[J].2003,306(1).
[62]Cosentino M.,Maestroni GJM.,Rasini E.,etc.HPLC-ED measurement of endogenous catecholamines in human immune cells and hematopoietic cell lines[J].2000,68(3).
[63]Zhang,Y.,Li,X.-F.,Song,J.,etc.Dopamine D1 receptors mediate dopamine-induced duodenal epithelial ion transport in rats[J].2013,161(6).
[64]Szasz,J.,Borgohain,R.,Avarello,T.,etc.Two-Year, randomized, controlled study of safinamide as add-on to levodopa in mid to late Parkinson's disease[J].2014,29(10).
[65]Estan L,Martinez Abad M,Aguilar MJ,etc.Effects of dopamine in isolated rat colon strips.[J].2005,83(6).
[66]Dasgupta PS,Basu S,Basu B,etc.The immunoregulatory role of dopamine: an update.[J].2010,24(4).
[67]Eva Mezey,Gyongyi Harta,Graeme Eisenhofer.A novel nonneuronal catecholaminergic system: Exocrine pancreas synthesizes and releases dopamine[J].1996,93(19).
[68]Jandaghi, Pouria,Najafabadi, Hamed S.,Bauer, Andrea S.,etc.Expression of DRD2 Is Increased in Human Pancreatic Ductal Adenocarcinoma and Inhibitors Slow Tumor Growth in Mice[J].2016,151(6).
[69]Yasuhara H,Yamada M.Clinical Pharmacology of MAO Inhibitors: Safety and Future.[J].2004,25(1).
[70]Greene JG,Anderson G,Taylor G,etc.Loss of enteric dopaminergic neurons and associated changes in colon motility in an MPTP mouse model of Parkinson's disease.[J].2007,207(1).
[71]Kim, Dohoon,Kim, Wooseong,Jeong, Seongkeun,etc.Therapeutic switching of sulpiride, an anti-psychotic and prokinetic drug, to an anti-colitic drug using colon-specific drug delivery[J].2019,9(1).
[72]Ratcliffe E,Li ZS,Gershon MD,etc.Physiological modulation of intestinal motility by enteric dopaminergic neurons and the D2 receptor: analysis of dopamine receptor expression, location, development, and function in wild-type and knock-out mice.[J].2006,26(10).
[73]Zheng,L.-F.,Song,J.,Fan,R.-F.,etc.The role of the vagal pathway and gastric dopamine in the gastroparesis of rats after a 6-hydroxydopamine microinjection in the substantia nigra[J].2014,211(2).
[74]Marco, Cosentino,Anna Maria, Fietta,Marco, Ferrari,etc.Human CD4+CD25+ regulatory T cells selectively express tyrosine hydroxylase and contain endogenous catecholamines subserving an autocrine/paracrine inhibitory functional loop.[J].2007,109(2).
[75]R Caldara,C Ferrari,M Romussi,etc.Effect of dopamine infusion on gastric and pancreatic secretion and on gastrin release in man.[J].1978,19(8).
[76]M, Da Prada,G, Zürcher,I, Wüthrich,etc.On tyramine, food, beverages and the reversible MAO inhibitor moclobemide.[J].1988,26.
[77]Wei Shao,Shu-zhen Zhang,Mi Tang,etc.Suppression of neuroinflammation by astrocytic dopamine D2 receptors via αB-crystallin[J].2013,494(Feb.7 TN.7435).
[78]G B, Glavin,A M, Hall.Central and peripheral dopamine D1/DA1 receptor modulation of gastric secretion and experimental gastric mucosal injury.[J].1995,26(6).
[79]V A, Shishov,T A, Kirovskaia,V S, Kudrin,etc.[Amine neuromediators, their precursors, and oxidation products in the culture of Escherichia coli K-12].[J].1900,45.
[80]M K, Barry,M M, Maher,J D, Gontarek,etc.Luminal dopamine modulates canine ileal water and electrolyte transport.[J].1995,40(8).
[81]Puiman, P. J.,Bouma, J.,Goudoever, J. B. van,etc.The regulation of intestinal mucin MUC2 expression by short-chain fatty acids: implications for epithelial protection.[J].2009,420(2).
[82]Xiao, Han,Bin, Li,Xin, Ye,etc.Dopamine D2 receptor signalling controls inflammation in acute pancreatitis via a PP2A-dependent Akt/NF-κB signalling pathway.[J].2017,(Spec ).
[83]Pacheco,R.,González,H.,Díaz,P.,etc.Stimulation of dopamine receptor D5 expressed on dendritic cells potentiates Th17-mediated immunity[J].2012,188(7).
[84]Dezsi, Livia,Vecsei, Lzszlo.Monoamine Oxidase B Inhibitors in Parkinson's Disease[J].2017,16(4).
[85]Yasunari Asano,Tetsuya Hiramoto,Ryo Nishino,etc.Critical role of gut microbiota in the production of biologically active, free catecholamines in the gut lumen of mice[J].2012,303(6 Pt.1).
[86]Tammimaki A,Kaenmaki M,Garcia Horsman J.Importance of membrane-bound catechol-O-methyltransferase in L-DOPA metabolism: a pharmacokinetic study in two types of Comt gene modified mice.[J].2009,158(8).
[87]Weintraub, Daniel,Hauser, Robert A.,Elm, Jordan J.,etc.Rasagiline for mild cognitive impairment in Parkinson's disease: A placebo-controlled trial[J].2016,31(5).
[88]Dasgupta PS,Eckelhoefer IA,Vasile E,etc.The neurotransmitter dopamine inhibits angiogenesis induced by vascular permeability factor/vascular endothelial growth factor.[J].2001,7(5).