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Research advances in regulating mechanisms of mammalian ovarian folliculogenesis

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Author:: No author available

Journal Title:: Acta Physiologica Sinica

Issue:: 1

DOI:: 10.13294/j.aps.2019.0086

Key Word:: 卵巢;卵泡;信号通路;动物模型;生殖寿命

Abstract：卵巢作为雌性哺乳动物的性腺,是由卵母细胞和不同类型的体细胞组成的异质性器官.卵巢在功能上,一方面担负了与雌性个体健康有关的内分泌调节功能,另一方面则承载了产生成熟卵母细胞并繁衍子代的重要任务.而承担上述功能的单位为卵泡,即卵母细胞和卵泡体细胞共同构成的复合体.对于具有较长生殖寿命的哺乳动物而言,卵泡在卵巢内的发育是一个内部协同与外部调控的精密有序过程.其中后期促性腺激素依赖的有腔卵泡发育直接调控生殖周期的产生,而近期越来越多的证据表明早期卵泡的有序发育与雌性生殖寿命维持密切关联.因此,卵泡在体正常发育与雌性个体的健康息息相关;而深入探索卵泡发育调控机制,可直接指导我们认识包括人类在内的雌性哺乳动物生殖寿命的维持机制,并在未来对其进行可能的调控.近年来,伴随着新技术和新方法的产生,特别是基因修饰动物的开发以及新型显微技术的出现,对卵泡发育特别是早期卵泡发育的调控机制研究有了长足的进步.本综述围绕着卵泡在体发育中的关键生理事件,将近年来对卵泡的生理发育调节机制研究进行梳理,并重点聚焦于早期卵泡发育的体内相关调控机制研究进展.

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