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Exosomes and their roles in diabetes mellitus and its complications: from pathogenic, diagnostic and therapeutical perspectives

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Author:: No author available

Journal Title:: Acta Physiologica Sinica

Issue:: 6

DOI:: 10.13294/j.aps.2019.0059

Key Word:: 外泌体;糖尿病;糖尿病并发症

Abstract：外泌体是一种纳米级大小,由细胞主动吞吐而分泌的具有膜结构的细胞外囊泡样小体,可以携带和转移很多生物分子,如DNA片段、环状RNA (circRNA)、mRNA、微小RNA (miRNA)、功能蛋白、转录因子等,从而成为细胞间信息传递的载体.近年来外泌体与糖尿病的关系受到广泛关注,它们在胰岛素敏感性、葡萄糖稳态、血管内皮功能等方面发挥重要作用.本文综述外泌体参与糖尿病及其并发症的病理生理过程,并探讨了外泌体作为糖尿病治疗的靶点及其在糖尿病的诊断与治疗中的作用和前景.

Reference

[1]罗艳,胡桂英.2型糖尿病肾病患者尿液外泌体中miRNA的表达谱分析研究[J].2017,(9).
[2]郭磊,吕静,刘继军,等.肥胖患者内脏脂肪细胞来源的外泌体miRNAs表达谱分析[J].2018,(21).
[3]孙爱丽,胡晓燕,关广聚,等.尿胞外体亮氨酸氨基肽酶及二肽基肽酶在糖尿病肾病中的变化[J].2011,(4).
[4]贝毅桦,喻溥蛟,肖俊杰.小囊泡中的大学问--外泌体的前世今生[J].2017,(3).
[5]Daria A, Narmoneva,Rada, Vukmirovic,Michael E, Davis,etc.Endothelial cells promote cardiac myocyte survival and spatial reorganization: implications for cardiac regeneration.[J].2004,110.
[6]Tian,Su,Yuzhong,Xiao,Ye,Xiao,etc.Bone Marrow Mesenchymal Stem Cells-Derived Exosomal MiR-29b-3p Regulates Aging-Associated Insulin Resistance.[J].2019,13(2).
[7]Jung-Ah Cho,Dong-jun Yeo,Hye-Youn Son,etc.Exosomes: A new delivery system for tumor antigens in cancer immunotherapy[J].2005,114(4).
[8]Ertunc, Meric Erikci,Sikkeland, Jorgen,Fenaroli, Federico,etc.Secretion of fatty acid binding protein aP2 from adipocytes through a nonclassical pathway in response to adipocyte lipase activity[J].2015,56(2).
[9]Scheffer,M.P.,Zeiher,A.M.,Boon,R.A.,etc.Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs[J].2012,14(3).
[10]Glenda M, Davison,Bongani B, Nkambule,Zibusiso, Mkandla,etc.Platelet, monocyte and neutrophil activation and glucose tolerance in South African Mixed Ancestry individuals.[J].2017,7(Spec ).
[11]Mori,M.A.,Thomou,T.,Boucher,J.,etc.Altered miRNA processing disrupts brown/white adipocyte determination and associates with lipodystrophy[J].2014,124(8).
[12]Nanthini,Jayabalan,Andrew,Lai,Soumyalekshmi,Nair,etc.Quantitative Proteomics by SWATH-MS Suggest an Association Between Circulating Exosomes and Maternal Metabolic Changes in Gestational Diabetes Mellitus.[J].2018.
[13]Poy, Matthew N.,Eliasson, Lena,Krutzfeldt, Jan,etc.A pancreatic islet-specific microRNA regulates insulin secretion.[J].2004,432(7014).
[14]Tamara,Sáez,Paul,de Vos,Jeroen,Kuipers,etc.Exosomes derived from monocytes and from endothelial cells mediate monocyte and endothelial cell activation under high d-glucose conditions.[J].2019,224(2).
[15]Xu, M.,Liu, B.,Wu, M-F,etc.Relationships among acylation-stimulating protein, insulin resistance, lipometabolism, and fetal growth in gestational diabetes mellitus women[J].2015,35(4).
[16]Shi, Ruijing,Zhao, Lianbi,Cai, Wenbin,etc.Maternal exosomes in diabetes contribute to the cardiac development deficiency[J].2017,483(1).
[17]Ralph A, DeFronzo,Ele, Ferrannini,Leif, Groop,etc.Type 2 diabetes mellitus.[J].2015,1.
[18]Hala Aswad,Alexis Forterre,Oscar P. B. Wikler,etc.Exosomes participate in the alteration of muscle homeostasis during lipid-induced insulin resistance in mice[J].2014,57(10).
[19]Ulrich Hink,Huige Li,Hanke Mollnau,etc.Mechanisms Underlying Endothelial Dysfunction in Diabetes Mellitus[J].2001,88(2).
[20]Jin, Li,Ling-Zhi, Fu,Lu, Liu,etc.Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist Liraglutide Alters Bone Marrow Exosome-Mediated miRNA Signal Pathways in Ovariectomized Rats with Type 2 Diabetes.[J].2017,23(Spec ).
[21]Alexander J. Lakhter,Rachel E. Pratt,Linda A. DiMeglio,etc.Beta cell extracellular vesicle miR-21-5p cargo is increased in response to inflammatory cytokines and serves as a biomarker of type 1 diabetes[J].2018,61(5).
[22]Michalek S,Poliakov A,Wang J,etc.Adipose tissue exosome-like vesicles mediate activation of macrophage-induced insulin resistance.[J].2009,58(11).
[23]Wigard P, Kloosterman,Anne K, Lagendijk,René F, Ketting,etc.Targeted inhibition of miRNA maturation with morpholinos reveals a role for miR-375 in pancreatic islet development.[J].2007,5(8).
[24]Rahman,M.J.,Regn,D.,Bashratyan,R.,etc.Exosomes released by islet-derived mesenchymal stem cells trigger autoimmune responses in NOD mice[J].2014,63(3).
[25].Extracellular vesicle-mimetic nanovesicles transport LncRNA-H19 as competing endogenous RNA for the treatment of diabetic wounds.[J].2018,25(1).
[26]Anuradha, Kalani,Aradhana, Mohan,Madan M, Godbole,etc.Wilm's tumor-1 protein levels in urinary exosomes from diabetic patients with or without proteinuria.[J].2013,8(3).
[27]Ahlee,Kim,Amy S,Shah,Takahisa,Nakamura.Extracellular Vesicles: A Potential Novel Regulator of Obesity and Its Associated Complications.[J].2018,5(11).
[28]Chaturvedi, Pankaj,Kalani, Anuradha,Medina, Ilza,etc.Cardiosome mediated regulation of MMP9 in diabetic heart: role of mir29b and mir455 in exercise[J].2015,19(9).
[29]Bodo C,Melnik,Gerd,Schmitz.Exosomes of pasteurized milk: potential pathogens of Western diseases.[J].2019,17(1).
[30]McCrae,K.R.,Kashyap,S.R.,Kirwan,J.P.,etc.Restoration of glycemic control in patients with type 2 diabetes mellitus after bariatric surgery is associated with reduction in microparticles[J].2013,9(2).
[31]Juan,Jin,Yifen,Shi,Jianguang,Gong,etc.Exosome secreted from adipose-derived stem cells attenuates diabetic nephropathy by promoting autophagy flux and inhibiting apoptosis in podocyte.[J].2019,10(1).
[32]Guay, Claudiane,Regazzi, Romano..Exosomes as new players in metabolic organ cross-talk.[J].2017,19.
[33]Marcelo F. Di Carli,James Janisse,Joel Ager,etc.Role of chronic hyperglycemia in the pathogenesis of coronary microvascular dysfunction in diabetes[J].2003,41(8).
[34]Dai, Yang D.,Dias, Peter.Exosomes or Microvesicles, a Secreted Subcellular Organelle Contributing to Inflammation and Diabetes[J].2018,67(11).
[35]Haney, Matthew J.,Klyachko, Natalia L.,Zhaoa, Yuling,etc.Exosomes as drug delivery vehicles for Parkinson's disease therapy[J].2015,207.
[36]Lara, Stevanato,Lavaniya, Thanabalasundaram,Nickolai, Vysokov,etc.Investigation of Content, Stoichiometry and Transfer of miRNA from Human Neural Stem Cell Line Derived Exosomes.[J].2016.
[37]Parrizas, Marcelina,Brugnara, Laura,Esteban, Yaiza,etc.Circulating miR-192 and miR-193b Are Markers of Prediabetes and Are Modulated by an Exercise Intervention[J].2015,100(3).
[38]B. W. M. van Balkom,M. W. L. Schuchardt,K. R. Vrijsen,etc.Cardiomyocyte progenitor cell-derived exosomes stimulate migration of endothelial cells[J].2010,14(5).
[39]Schnoor, Michael.Endothelial Actin-Binding Proteins and Actin Dynamics in Leukocyte Transendothelial Migration[J].2015,194(8).
[40]Denis,Delić,Claudia,Eisele,Ramona,Schmid,etc.Urinary Exosomal miRNA Signature in Type II Diabetic Nephropathy Patients.[J].2016,11(3).
[41]Tang,K.,Xiao,Y.,Liu,D.,etc.Autografting of bone marrow mesenchymal stem cells alleviates streptozotocin-induced diabetes in miniature pigs: Real-time tracing with MRI in vivo[J].2014,33(6).
[42]Cupples LA,Meigs JB,Wilson PW.Parental transmission of type 2 diabetes: the Framingham Offspring Study.[J].2000,49(12).
[43]Huang, Chao,Fisher, Kiera P.,Hammer, Sandra S.,etc.Plasma Exosomes Contribute to Microvascular Damage in Diabetic Retinopathy by Activating the Classical Complement Pathway[J].2018,67(8).
[44]Marta, Garcia-Contreras,Sanket H, Shah,Alejandro, Tamayo,etc.Plasma-derived exosome characterization reveals a distinct microRNA signature in long duration Type 1 diabetes.[J].2017,7(1).
[45]David P. Bartel.MicroRNAs: Target Recognition and Regulatory Functions[J].2009,136(2).
[46].AngiomiR-126 expression and secretion from circulating CD34+ and CD14+ PBMCs: Role for proangiogenic effects and alterations in type 2 diabetics[J].2013,121(1).
[47]Davidson, Sean M.,Riquelme, Jaime A.,Takov, Kaloyan,etc.Cardioprotection mediated by exosomes is impaired in the setting of type II diabetes but can be rescued by the use of non-diabetic exosomes in vitro[J].2018,22(1).
[48]A,Safwat,D,Sabry,A,Ragiae,etc.Adipose mesenchymal stem cells-derived exosomes attenuate retina degeneration of streptozotocin-induced diabetes in rabbits.[J].2018,7.
[49]Günter, Müller.Microvesicles/exosomes as potential novel biomarkers of metabolic diseases.[J].2012,5.
[50]Yang, Zhi,Hu, Jianqiang,Xiong, Zhenyu,etc.Exosomal Mst1 transfer from cardiac microvascular endothelial cells to cardiomyocytes deteriorates diabetic cardiomyopathy[J].2018,1864(11).
[51]Chun-Yuan, Chen,Shan-Shan, Rao,Lu, Ren,etc.Exosomal DMBT1 from human urine-derived stem cells facilitates diabetic wound repair by promoting angiogenesis.[J].2018,8(6).
[52]Donato, Santovito,Velia, De Nardis,Pamela, Marcantonio,etc.Plasma exosome microRNA profiling unravels a new potential modulator of adiponectin pathway in diabetes: effect of glycemic control.[J].2014,99(9).
[53]Marta, Alenquer,Maria Jo?o, Amorim.Exosome Biogenesis, Regulation, and Function in Viral Infection.[J].2015,7(9).
[54]Zhen-yu YAO,Wen-bin CHEN,Shan-shan SHAO,etc.外泌体相关的microRNA在代谢性疾病诊断和治疗中的作用[J].2018,(3).
[55]Tang, Norina,Sun, Bing,Gupta, Archana,etc.Monocyte exosomes induce adhesion molecules and cytokines via activation of NF-B in endothelial cells[J].2016,30(9).
[56]Xiaohong Wang,Wei Huang,Guansheng Liu,etc.Cardiomyocytes mediate anti-angiogenesis in type 2 diabetic rats through the exosomal transfer of miR-320 into endothelial cells[J].2014,74.
[57]Ming,Song,Lu,Han,Fang-Fang,Chen,etc.Adipocyte-Derived Exosomes Carrying Sonic Hedgehog Mediate M1 Macrophage Polarization-Induced Insulin Resistance via Ptch and PI3K Pathways.[J].2018,48(4).
[58]Clair,Crewe,Nolwenn,Joffin,Joseph M,Rutkowski,etc.An Endothelial-to-Adipocyte Extracellular Vesicle Axis Governed by Metabolic State.[J].2018,175(3).
[59]Ying, Wei,Riopel, Matthew,Bandyopadhyay, Gautam,etc.Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity[J].2017,171(2).
[60]Nesrine,Ebrahim,Inas A,Ahmed,Noha I,Hussien,etc.Mesenchymal Stem Cell-Derived Exosomes Ameliorated Diabetic Nephropathy by Autophagy Induction through the mTOR Signaling Pathway.[J].2018,7(12).
[61]Gudehithlu, Krishnamurthy P.,Garcia-Gomez, Ignacio,Vernik, Jane,etc.In Diabetic Kidney Disease Urinary Exosomes Better Represent Kidney Specific Protein Alterations Than Whole Urine[J].2015,42(6).
[62]Justyna,Janikiewicz,Paulina,Pawelec,Patrycja,Kucharczyk,etc.The Good, the Bad, and the Ugly - role of the pancreas, endothelium, and adipose tissue axis in the management of pancreatic β-cell failure in obesity-related type 2 diabetes.[J].2018,64(2).
[63]Poy, Matthew N.,Hausser, Jean,Trajkovski, Mirko,etc.miR-375 maintains normal pancreatic α-and β-cell mass.[J].2009,106(14).
[64]Yu,Zhu,Yachao,Jia,Yanmao,Wang,etc.Impaired Bone Regenerative Effect of Exosomes Derived from Bone Marrow Mesenchymal Stem Cells in Type 1 Diabetes.[J].2019.
[65]Mori,M.A.,Raghavan,P.,Thomou,T.,etc.Role of microRNA processing in adipose tissue in stress defense and longevity[J].2012,16(3).
[66]Laxminarayana,Korutla,Michael R,Rickels,Robert W,Hu,etc.Noninvasive diagnosis of recurrent autoimmune type 1 diabetes after islet cell transplantation.[J].2019.
[67]Agouni, Abdelali,Ducluzeau, Pierre-Henri,Benameur, Tarek,etc.Microparticles from Patients with Metabolic Syndrome Induce Vascular Hypo-Reactivity via Fas/Fas-Ligand Pathway in Mice.[J].2011,6(11).
[68]Nanthini,Jayabalan,Andrew,Lai,Valeska,Ormazabal,etc.Adipose Tissue Exosomal Proteomic Profile Reveals a Role on Placenta Glucose Metabolism in Gestational Diabetes Mellitus.[J].2019,104(5).
[69]Yuasa, Tomoyuki,Amo-Shiinoki, Kikuko,Ishikura, Shuhei,etc.Sequential cleavage of insulin receptor by calpain 2 and gamma-secretase impairs insulin signalling[J].2016,59(12).
[70]Gérard Ailhaud.Adipose tissue as a secretory organ: from adipogenesis to the metabolic syndrome[J].2006,329(8).
[71]Hassanpour, Mehdi,Cheraghi, Omid,Brazvan, Belal,etc.Chronic Exposure of Human Endothelial Progenitor Cells to Diabetic Condition Abolished the Regulated Kinetics Activity of Exosomes.[J].2018,17(3).
[72]Jessica L. Harding,Meda E. Pavkov,Dianna J. Magliano,etc.Global trends in diabetes complications: a review of current evidence[J].2019,62(1).
[73]Attane, Camille,Peyot, Marie-Line,Lussier, Roxane,etc.A beta cell ATGL-lipolysis/adipose tissue axis controls energy homeostasis and body weight via insulin secretion in mice[J].2016,59(12).
[74]Garcia, Nahuel A.,Moncayo-Arlandi, Javier,Sepulveda, Pilar,etc.Cardiomyocyte exosomes regulate glycolytic flux in endothelium by direct transfer of GLUT transporters and glycolytic enzymes[J].2016,109(3).
[75]Claudiane, Guay,Véronique, Menoud,Sophie, Rome,etc.Horizontal transfer of exosomal microRNAs transduce apoptotic signals between pancreatic beta-cells.[J].2015,13.
[76]Muller G.Control of lipid storage and cell size between adipocytes by vesicle-associated glycosylphosphatidylinositol-anchored proteins.[J].2011,117(1).
[77]Cheng, Qnqin,Shi, Xiaojing,Han, Menglu,etc.Reprogramming Exosomes as Nanoscale Controllers of Cellular Immunity[J].2018,140(48).
[78]Thomou, Thomas,Mori, Marcelo A.,Dreyfuss, Jonathan M.,etc.Adipose-derived circulating miRNAs regulate gene expression in other tissues[J].2017,542(Feb.23 TN.7642).
[79]Aleksandra, Tokarz,Iwona, Szu?cik,Beata, Ku?nierz-Cabala,etc.Extracellular vesicles participate in the transport of cytokines and angiogenic factors in diabetic patients with ocular complications.[J].2015,55.
[80]T. ?TULC,H. SVOBODOVá,Z. KRUPI?KOVá,etc.Rosiglitazone Influences the Expression of Leukocyte Adhesion Molecules and CD14 Receptor in Type 2 Diabetes Mellitus Patients[J].2014,63(Suppl.2).
[81]Posada-Ayala,M.,Fernandez-Fernandez,B.,Calvo,E.,etc.Diabetic nephropathy induces changes in the proteome of human urinary exosomes as revealed by label-free comparative analysis[J].2014,96.
[82]Tang, Li-Qin,Wei, Wei,Wang, Ying-Ying.Berberine attenuates podocytes injury caused by exosomes derived from high glucose-induced mesangial cells through TGF beta 1-PI3K/AKT pathway[J].2018,824.
[83]Fariba, Raygan,Fereshteh, Bahmani,Ebrahim, Kouchaki,etc.Comparative effects of carbohydrate versus fat restriction on metabolic profiles, biomarkers of inflammation and oxidative stress in overweight patients with Type 2 diabetic and coronary heart disease: A randomized clinical trial.[J].2016,(6).
[84]Wang, Xiaohong,Gu, Haitao,Huang, Wei,etc.Hsp20-Mediated Activation of Exosome Biogenesis in Cardiomyocytes Improves Cardiac Function and Angiogenesis in Diabetic Mice[J].2016,65(10).
[85]Evans, Michele K.,Zhang, Yongqing,Becker, Kevin G.,etc.Altered Extracellular Vesicle Concentration, Cargo, and Function in Diabetes[J].2018,67(11).
[86]Ribeiro, Diana,Horvath, Istvan,Heath, Nikki,etc.Extracellular vesicles from human pancreatic islets suppress human islet amyloid polypeptide amyloid formation[J].2017,114(42).
[87]Noemí, García-Romero,Josefa, Carrión-Navarro,Susana, Esteban-Rubio,etc.DNA sequences within glioma-derived extracellular vesicles can cross the intact blood-brain barrier and be detected in peripheral blood of patients.[J].2017,8(1).
[88]Hur, Jaehark,Park, Sun,Kim, Kyongmin,etc.Molecular mechanisms of biogenesis of apoptotic exosome-like vesicles and their roles as damage-associated molecular patterns[J].2018,115(50).
[89]Wendt, Anna,Esguerra, Jonathan L. S.,Eliasson, Lena.Islet microRNAs in health and type-2 diabetes[J].2018,43.
[90]Jalabert, Audrey,Vial, Guillaume,Guay, Claudiane,etc.Exosome-like vesicles released from lipid-induced insulin-resistant muscles modulate gene expression and proliferation of beta recipient cells in mice[J].2016,59(5).
[91]Andrew S, Kimball,Amrita D, Joshi,Anna E, Boniakowski,etc.Notch Regulates Macrophage-Mediated Inflammation in Diabetic Wound Healing.[J].2017,8(Spec ).
[92]Jin HM,Wang XH,Chen SF,etc.MicroRNA-320 expression in myocardial microvascular endothelial cells and its relationship with insulin-like growth factor-1 in type 2 diabetic rats.[J].2009,36(2).
[93]Tanaka C,Nakagawa Y,Nagasaki H,etc.Adipocyte-derived microvesicles contain RNA that is transported into macrophages and might be secreted into blood circulation.[J].2010,398(4).
[94]Wang, Zhi-hao,Ti, Yun,Li, Ya,etc.Insulin resistance adipocyte-derived exosomes aggravate atherosclerosis by increasing vasa vasorum angiogenesis in diabetic ApoE(-/-) mice[J].2018,265.
[95]L L, Zhu,X, Huang,W, Yu,etc.Transplantation of adipose tissue-derived stem cell-derived exosomes ameliorates erectile function in diabetic rats.[J].2017,(Spec ).
[96]Castano, Carlos,Kalko, Susana,Novials, Anna,etc.Obesity-associated exosomal miRNAs modulate glucose and lipid metabolism in mice[J].2018,115(48).
[97]Willeit J,Willeit P,Kiechl S,etc.Plasma microRNA profiling reveals loss of endothelial miR-126 and other microRNAs in type 2 diabetes.[J].2010,107(6).
[98]Shahrzad,Nojehdehi,Sara,Soudi,Ardeshir,Hesampour,etc.Immunomodulatory effects of mesenchymal stem cell-derived exosomes on experimental type-1 autoimmune diabetes.[J].2018.
[99]Zahra, Karimi,Farima, Kahe,Adeel, Jamil,etc.Intercellular adhesion molecule-1 in diabetic patients with and without microalbuminuria.[J].2017,(Spec ).
[100]Hubal, Monica J.,Nadler, Evan P.,Ferrante, Sarah C.,etc.Circulating Adipocyte-Derived Exosomal MicroRNAs Associated with Decreased Insulin Resistance After Gastric Bypass[J].2017,25(1).
[101]Kenta,Kubota,Masako,Nakano,Eiji,Kobayashi,etc.An enriched environment prevents diabetes-induced cognitive impairment in rats by enhancing exosomal miR-146a secretion from endogenous bone marrow-derived mesenchymal stem cells.[J].2018,13(9).
[102]Judy L. Aschner,Jian-Xiong Chen,Jeff Reese,etc.Overexpression of angiopoietin-2 impairs myocardial angiogenesis and exacerbates cardiac fibrosis in the diabetic db/db mouse model[J].2012,302(2 Pt.2).
[103]Alessia, Gallo,Mayank, Tandon,Ilias, Alevizos,etc.The majority of microRNAs detectable in serum and saliva is concentrated in exosomes.[J].2012,7(3).
[104]Justyna, Mleczko,Francisco J, Ortega,Juan Manuel, Falcon-Perez,etc.Extracellular Vesicles from Hypoxic Adipocytes and obese subjects reduce Insulin-Stimulated Glucose Uptake.[J].2018,(Spec ).
[105]Takeshi, Katsuda,Reiko, Tsuchiya,Nobuyoshi, Kosaka,etc.Human adipose tissue-derived mesenchymal stem cells secrete functional neprilysin-bound exosomes.[J].2013,3.
[106]Saez, Tamara,de Vos, Paul,Kuipers, Jeroen,etc.Fetoplacental endothelial exosomes modulate high D-glucose-induced endothelial dysfunction[J].2018,66.
[107]Els J, van der Vlist,Ger J A, Arkesteijn,Chris H A, van de Lest,etc.CD4(+) T cell activation promotes the differential release of distinct populations of nanosized vesicles.[J].2012,1.
[108]Ricardo, Ladeiras-Lopes,Henrique T, Moreira,Nuno, Bettencourt,etc.Metabolic Syndrome is Associated with Impaired Diastolic Function Independently of Mri-Derived Myocardial Extracellular Volume: the Mesa Study.[J].2018,(Spec ).
[109]Luciano Ribeiro, Filgueiras,Stephanie L, Brandt,Soujuan, Wang,etc.Leukotriene B4-mediated sterile inflammation promotes susceptibility to sepsis in a mouse model of type 1 diabetes.[J].2015,8(361).
[110]Phoonsawat,W.,Aoki-Yoshida,A.,Tsuruta,T.,etc.Adiponectin is partially associated with exosomes in mouse serum[J].2014,448(3).
[111]Yang, Yu,Hongwei, Du,Shengnan, Wei,etc.Adipocyte-Derived Exosomal MiR-27a Induces Insulin Resistance in Skeletal Muscle Through Repression of PPARγ.[J].2018,8(8).
[112]Tamara,Saez,Fernando,Toledo,Luis,Sobrevia.Extracellular vesicles and insulin resistance: a potential interaction in vascular dysfunction.[J].2018.
[113]P.Westermark,K.H.Johnson,T.D.O'Brien,etc.Islet amyloid polypeptide - a novel controversy in diabetes research[J].1992,35(4).
[114]Froy, Oren,Barnea, Maayan,Genzer, Yoni,etc.The circadian clock machinery controls adiponectin expression[J].2015,399(Issue C).
[115]Sun, Yaoxiang,Shi, Hui,Yin, Siqi,etc.Human Mesenchymal Stem Cell Derived Exosomes Alleviate Type 2 Diabetes Mellitus by Reversing Peripheral Insulin Resistance and Relieving beta-Cell Destruction[J].2018,12(8).
[116]Cheerathodi, Mujeeb R.,Tremblay, Deanna C.,Meckes, David G., Jr.,etc.Transmembrane Domains Mediate Intra- and Extracellular Trafficking of Epstein-Barr Virus Latent Membrane Protein 1[J].2018,92(17).
[117]Halvorsen, Bente,Santilli, Francesca,Scholz, Hanne,etc.LIGHT/TNFSF14 is increased in patients with type 2 diabetes mellitus and promotes islet cell dysfunction and endothelial cell inflammation in vitro[J].2016,59(10).
[118]Soumyalekshmi,Nair,Nanthini,Jayabalan,Dominic,Guanzon,etc.Human Placental Exosomes in Gestational Diabetes Mellitus Carry a Specific Set of miRNAs Associated with Skeletal Muscle Insulin Sensitivity.[J].2018.