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Signaling pathways controlling skeletal muscle mass

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Author:: No author available

Journal Title:: Acta Physiologica Sinica

Issue:: 4

DOI:: 10.13294/j.aps.2019.0021

Key Word:: 骨骼肌质量;肥大;萎缩;信号通路

Abstract：骨骼肌质量约占健康成人体重的40％.骨骼肌不仅直接参与运动,还作为分泌器官分泌多种肌肉因子影响其它器官的功能,因此骨骼肌功能的维持对机体健康具有重要意义.骨骼肌质量作为骨骼肌功能的基础,常常受到运动、疾病等多种因素的影响.如抗阻运动可引起骨骼肌细胞蛋白质合成增加,诱发肌肉肥大;而肢体废用、慢性阻塞性肺疾病、心衰、慢性肾病、恶病质、杜氏肌营养不良等疾病可导致骨骼肌细胞蛋白质合成降低或降解增强,引起肌肉萎缩.骨骼肌肥大或萎缩的过程涉及多条信号通路的改变,如IGF-1/PI3K/Akt、肌肉生长抑制素、G蛋白等介导的信号通路参与了骨骼肌肥大的调控;而泛素-蛋白酶体途径、IGF-1/Akt/FoxO、自噬-溶酶体途径、NF-κB及糖皮质激素介导的信号通路则在调节肌肉萎缩中发挥重要作用.这些信号通路在不同的条件下被激活或抑制,共同调节骨骼肌质量.本文综述骨骼肌质量控制信号通路及其主要转导机制,以加深对骨骼肌质量调控的理解与认识.

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