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Serotonergic neurons in the median raphe nucleus mediate anxiety-and depression-like behavior

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Author:: No author available

Journal Title:: Acta Physiologica Sinica

Issue:: 3

DOI:: 10.13294/j.aps.2018.0044

Key Word:: 5-羟色胺;中缝中核;焦虑;抑郁

Abstract：中枢神经递质中,5-羟色胺(5-hydroxtryptamine,5-HT)作用广泛,对情绪调节、感觉传输和认知行为等都有重要调节作用.5-HT能神经元数量较少,主要分布于脑干中线的中缝背核(dorsal raphe nucleus,DR)和中缝中核(median raphe nucleus,MR).之前的研究主要聚焦于DR核团的功能,对MR核团5-HT能神经元的功能知之甚少.本研究以Petl-Cre转基因小鼠作为研究对象,通过DREADDs技术特异性操控MR核团5-HT能神经元的活动,进而观察MR核团5-HT能神经元在焦虑和抑郁样行为中的作用.结果显示,在旷场实验与高架十字迷宫实验中,抑制小鼠MR核团5-HT能神经元能减轻小鼠焦虑样行为.在蔗糖偏爱实验和强迫游泳实验中,抑制小鼠MR核团5-HT能神经元能减轻小鼠抑郁样行为,激活MR核团5-HT能神经元则增强小鼠的抑郁样行为.这些结果提示MR核团5-HT能神经元在调节焦虑和抑郁样行为中发挥关键性作用.

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