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L-VDCC autoregulation abnormality contributes to calcium overload in myocardial ischemia-reperfusion injury

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Journal Title:
Acta Physiologica Sinica
Key Word:
心脏;缺血再灌注损伤;钙超载;L-型电压依赖钙通道;heart;ischemia-reperfusion injury;calcium overload;L-type voltage-dependent calcium channel

Abstract´╝Ü Calcium overload is a vital mechanism of myocardial ischemia-reperfusion injury,which is a hot therapeutic target in cardiovascular research.It has been well recognized that the dysfunction of calcium relevant proteins,including L-type voltagedependent calcium channel (L-VDCC),sarco/endoplasmic reticulum ATPase 2a (SERCA2a)/phospholamban (PLB),RyR2,Na+/Ca2+ exchanger,Na+/H+ exchanger,etc.contributes to calcium overload in cardiomyocytes during ischemia-reperfusion injury,in which the diastolic calcium concentration is increased and the amplitude of calcium transients is decreased.There are two phases in calcium increase.The early phase is partially mediated by calcium channels,and the latter one is mainly mediated by Na+/Ca2+ exchanger.L-VDCC,a main subtype of calcium channels in myocardium,is involved in calcium overload,but the underlying molecular mecha nism is not well elucidated yet.L-VDCC is regulated by intrinsic and extrinsic pathways.PKG and PKA as extrinsic regulators are not proper candidates to increase L-VDCC activity of cardiomyocyte in vitro,whereas the myocardial ischemia-reperfusion injury is highly possible to enhance L-VDCC activity by delaying calcium-dependent inactivation (CDI),advancing calcium-dependent facilitation (CDF),and weakening distal carboxy terminus (DCT) inhibition.Therefore,it is rational to propose that the L-VDCC autoregulation abnormality may play an important role in calcium overload during myocardial ischemia-reperfusion injury.

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