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Potassium channels and autophagy

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Author:: No author available

Journal Title:: Acta Physiologica Sinica

Issue:: 4

DOI:: 10.13294/j.aps.2017.0038

Key Word:: 离子通道;钾通道;自噬;ion channel;potassium channel;autophagy

Abstract： Potassium channels have multitudinous subtypes,which are widely distributed on cell membranes.They affect various cellular physiological functions through participating in processes such as resting potential formation,substance transportation,enzyme activity and cellular communication.Autophagy is a significant mechanism to maintain intracellular metabolic homeostasis.The abnormity of autophagy may lead to the occurrence and development of multiple diseases.Recently,it has been reported that K+ channels and cell autophagy are closely related.Here,we reviewed the recent research progresses on regulation of autophagy signaling,autophagy flux or autophagolysosome formation by K+ channel,and discussed the physiological significance of autophagy regulation by K+ channel.

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