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Empathy for pain: A novel bio-psychosocial-behavioral laboratory animal model

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Author:: No author available

Journal Title:: Acta Physiologica Sinica

Issue:: 6

DOI:: 10.13294/j.aps.2015.0069

Key Word:: 共情;亲社会行为;疼痛;情绪;empathy;prosocial behavior;pain;emotion

Abstract：疼痛共情是一种亲社会行为,是一种能够理解和分享他人情绪状态的能力.从广义上讲,共情也是利他主义的社会行为学基础.共情发育受损可能与自闭症、自恋症、人格障碍、精神分裂症和抑郁等发生密切相关.研究共情的脑机理不仅具有重要的科学和临床意义,还具有普遍的社会意义.然而,由于共情一直被认为是人之所以区别于其它动物的主要特征,所以长期以来很少有学者触及,致使这个领域一直处于空白状态.2006年加拿大麦吉尔大学一个研究组首先发现一只处于疼痛状态的小鼠可以在社交时通过情绪传染把疼痛传染给它的同笼伴侣,使其痛阈下降,痛反应增强,但陌生者间无此现象.2014年我们实验室又发现一只大鼠在与处于疼痛状态的同笼大鼠社交30 min后,痛阈仍下降,痛反应仍增强,提示疼痛共情可长时间持续(共情记忆).我们还探查出内侧前额叶(包括前扣带回、前边缘皮质、下边缘皮质)参与大鼠的疼痛共情持续,提示中枢神经系统内存在一个与疼痛共情有关的神经网络环路.本文将简要介绍人和啮齿类动物疼痛共情的研究现状和挑战,旨在为研究疼痛及其情绪共病提供一个新的模型和研究思路,更为认识脑功能提供一个生物-社会心理-行为学研究范式.

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