GABA mediaties the inhibitory effect of lateral amygdaloid nucleus stimulation on the acoustic response of neurons in A Ⅰ cortex:An in vivo microiontophoretic study
- Author:
- No author available
- Journal Title:
- ACTA PHYSIOLOGICA SINICA
- Issue:
- 3
- DOI:
- 10.3321/j.issn:0371-0874.2004.03.017
- Key Word:
- 杏仁外侧核;皮层A Ⅰ区;声反应;抑制;GABA;lateral amygdaloid nucleus;A Ⅰ cortex;acoustic response;inhibition;GABA
Abstract： Experiments were performed on Sprague Dawley rats with multibarrel microelectrode technique. The effects of acoustic response of A Ⅰ cortex neurons produced by electrical stimulation of lateral amygdaloid nucleus (LA) and the influence of GABA were observed. Experimental results showed that iontophoretic administration of GABA caused a pronounced inhibition of the electrical activity of A- Ⅰ neurons. Blockade of GABAA with bicuculline (BIC) facilitated the acoustic response. The acoustic response of A- Ⅰ neurons was inhibited when the LA was stimulated. Iontophoretic application of GABA resulted in a similar inhibitory effect as that of LA stimulation. Blockade of GABAA with bicuculline reversed the inhibitory effect of LA stimulation on the acoustic response of A- Ⅰ neurons. In contrast, application of strychnine, a glycine receptor antagonist, could not reverse the inhibitory effect of LA. Baclofen, a GABAB agonist, did not affect the acoustic response of the auditory neurons. These results indicate that GABA is the ultimate transmitter which mediates the LA stimulation-induced inhibition of the acoustic response of A- Ⅰ neurons in rats, possibly via the GABAAreceptor.
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