You Position: Home > Paper
Effect of acetazolamide on the latency of hyperbaric oxygen-induced convulsion
( views:157, downloads:5 )
- Author:
- No author available
- Journal Title:
- ACTA PHYSIOLOGICA SINICA
- Issue:
- 2
- DOI:
- 10.3321/j.issn:0371-0874.2004.02.006
- Key Word:
- 高压氧;惊厥;乙酰唑胺;脑血流
Abstract： 为探讨脑血流调节与氧惊厥的关系,在复制大鼠氧惊厥模型的基础上,采用行为学方法测定氧惊厥潜伏期,并测定不同部位脑组织氧化与抗氧化指标,采用腹腔注射不同剂量脑血管扩张药物乙酰唑胺,观察脑血管扩张对氧化状态以及氧惊厥潜伏期的影响.观察结果为:(1)与生理盐水组相比,乙酰唑胺200、20 mg/kg体重组腹腔给药后氧惊厥潜伏期(纯氧6 ATA暴露)明显缩短(P＜0.01),乙酰唑胺2 mg/kg体重组无明显改变(P＞0.05);(2)腹腔给乙酰唑胺(20 mg/kg体重)或生理盐水后,各组各部位脑组织GSH-PX无显著差异(P＞0.05),但随暴露时间的延长,其活力呈现先升高后降低的趋势;与对照组相比,乙酰唑胺6min组和生理盐水16 min组皮层丙二醛(maleic dialdehyde,MDA)含量均明显增多(P＜0.01),乙酰唑胺16 min组海马MDA含量明显增多(P＜0.01).结果表明,乙酰唑胺可缩短氧惊厥潜伏期,加重脑组织氧化损伤.
- [1]Arieli, R.,Ertracht, O..Latency to CNS oxygen toxicity in rats as a function of PCO~2 and PO~2[J].1999,80(6).
- [2]R. Arieli.Latency of oxygen toxicity of the central nervous system in rats as a function of carbon dioxide production and partial pressure of oxygen[J].1998,78(5).
- [3]Deitmer JoachimW.A role for CO(2) and bicarbonate transporters in metabolic exchanges in the brain.[J].2002,80(5).
- [4]Noemi Bitterman,Shlomit Schaal.Caffeine attenuates CNS oxygen toxicity in rats[J].1995,696(1-2).
- [5]Dietrich HH,Hongo K,Goto T,etc.Role of endothelial nitric oxide and smooth muscle potassium channels in cerebral arteriolar dilation in response to acidosis.[J].2002,33(3).
- [6]Fridovich I..Oxygen toxicity: A radical explanation[J].1998,201(8).
- [7]Arieli,R,Rashkovan,G,Moskovitz,Y,etc.PCO(2) threshold for CNS oxygen toxicity in rats in the low range of hyperbaric PO(2).[J].2001,91(4).
- [8]Chavko, M.,Braisted, J. C.,Outsa, N. J.,etc.Role of cerebral blood flow in seizures from hyperbaric oxygen exposure[J].1998,791(1).