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Effect of peroxynitrite on the reactivity of rabbit pulmonary arteries in vitro
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- Author:
- No author available
- Journal Title:
- ACTA PHYSIOLOGICA SINICA
- Issue:
- 4
- DOI:
- No doi available
- Key Word:
- 过氧亚硝基阴离子;肺动脉;舒张反应;收缩反应
Abstract： 探讨过氧亚硝基阴离子(peroxynitrite, ONOO-)对离体兔肺动脉反应性变化的影响.用离体血管环技术观察ONOO-孵育后肺动脉对钙离子载体A23187、 ADP、 ACh、硝普钠(sodium nitroprusside, SNP)和苯肾上腺素(phenylephrine, PE)的反应性张力变化.结果显示: (1) ONOO-孵育后肺动脉对A23187、 ADP和ACh引起的舒张反应明显降低, ONOO-抑制内皮依赖受体依赖或受体非依赖性舒张反应有量效关系; (2) ONOO-孵育可剂量依赖性抑制肺动脉对SNP的舒张反应; (3) 0.5 mmol/L ONOO- 孵育后肺动脉对PE的收缩反应明显增强, 而1.0和2.0 mmol/L ONOO- 导致肺动脉的收缩反应明显降低; (4) 溶剂对肺动脉的反应性无明显影响, dec ONOO- 对PE和ADP的反应性影响不大, 但可增强A23187、 ACh和SNP的舒张反应.结果表明, ONOO- 可改变离体肺动脉的反应性.
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