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Phytoestrogen genistein inhibits carotid sinus baroreflex in anesthetized male rats
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- Author:
- No author available
- Journal Title:
- ACTA PHYSIOLOGICA SINICA
- Issue:
- 4
- DOI:
- 10.3321/j.issn:0371-0874.2002.04.016
- Key Word:
- 三羟异黄酮;Bay K 8644;压力感受器反射;平均动脉压
Abstract： 采用隔离灌流麻醉雄性大鼠颈动脉窦技术, 观察了植物雌激素三羟异黄酮(genistein, GST)对颈动脉窦压力感受器反射的影响.其结果如下: (1)以GST (50 μmol/L)隔离灌流颈动脉窦区时, 压力感受器机能曲线向右上方移位, 曲线最大斜率(peak slope, PS)由0.36±0.01降至0.23±0.01 (P<0.001), 反射性血压下降幅度(reflex decrease, RD)由39.75±1.58 降至27.00±0.60 mmHg (P<0.001), 阈压(TP)和饱和压(SP)分别从65.63±2.10和192.23±3.90升至82.05±1.95 mmHg (P<0.001)和215.76±3.75 mmHg (P<0.001).其中RD、PS和TP呈明显的剂量依赖性; (2)用Ca2+通道激动剂Bay K 8644 (500 nmol/L)预处理后, 能取消GST(50 μmol/L)对压力感受器反射的抑制作用; (3)预先灌流NO合酶阻断剂(L-NAME, 100 μmol/L), 不能阻断GST (50 μmol/L)对压力感受器反射的抑制效应.以上结果提示, GST可能通过阻断Ca2+通道途径而抑制大鼠颈动脉窦压力感受器反射, 并非由血管内皮细胞释放NO所致.
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