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Hemorrhagic shock induces changes in large-conductance Ca2+-dependent K+ channel activity in mesenteric arterial smooth muscle cells of rats
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- Author:
- No author available
- Journal Title:
- ACTA PHYSIOLOGICA SINICA
- Issue:
- 4
- DOI:
- 10.3321/j.issn:0371-0874.2001.04.011
- Key Word:
- 失血性休克;血管对去甲肾上腺素的反应性;大电导钙激活钾通道;血管平滑肌细胞;肠系膜动脉
Abstract： 在由股动脉放血制备的失血性休克大鼠模型急性分离的肠系膜动脉平滑肌细胞上,利用膜片箝单通道记录技术观察了血管平滑肌依钙K+通道(BKCa)的活动。发现在对去甲肾上腺素(NE)反应性增高的休克代偿期,BKCa的开放概率(Po)和单位电导都显著较正常动物的低,Po的改变主要是由通道的慢关闭时间常数(τcs)增大引起关闭时间延长所致;而处于对NE反应性降低的休克失代偿期,BKCa的Po和单位电导都高于正常动物,Po的变化也主要是τcs减小所致。
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