You Position: Home > Paper
EFFECTS OF GLUTAMATE ON TRANSIENT OUTWARD POTASSIUM CURRENT OF DISSOCIATED HIPPOCAMPAL NEURONS IN CA1 SECTOR IN RATS
( views:34, downloads:0 )
- Author:
- No author available
- Journal Title:
- ACTA PHYSIOLOGICA SINICA
- Issue:
- 1
- DOI:
- 10.3321/j.issn:0371-0874.1999.01.010
- Key Word:
- 谷氨酸;海马;神经元;电生理学
Abstract： 为了在离子通道水平探讨谷氨酸对急性分离海马CA1区神经元的短暂外向K+电流的影响.用7～10 d大鼠,以链霉蛋白酶E酶解加吸管吹打法制备海马CA1区神经元; 利用全细胞膜片箝技术,观察了谷氨酸对海马CA1区锥体细胞的短暂性K+电流的影响.结果观察到谷氨酸对短暂性K+电流有明显抑制作用,且呈明显浓度依赖性、时间依赖性和部分电压依赖性.上述结果表明,谷氨酸对K+通道的影响在中枢神经系统中具有重要作用.
- [1].Modulation of a transient outward current in serotonergic neurones by1-adrenoceptors[J].1985,315(6019).
- [2]R, Schmidt-Kastner,T F, Freund.Selective vulnerability of the hippocampus in brain ischemia.[J].1991,40(3).
- [3]J V, Halliwell,I B, Othman,A, Pelchen-Matthews,etc.Central action of dendrotoxin: selective reduction of a transient K conductance in hippocampus and binding to localized acceptors.[J].1986,83.
- [4]John W. Olney.Brain Lesions, Obesity, and Other Disturbances in Mice Treated with Monosodium Glutamate[J].1969,164(3880).
- [5]Wong RK,Choi DW,Chen QX,etc.Secondary activation of a cation conductance is responsible for NMDA toxicity in acutely isolated hippocampal neurons.[J].1997,17(11).
- [6]D W, Choi.Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage.[J].1988,11(10).