Abstract： Gastric carcinoma occurrence is strongly associated with genetic and epigenetic changes.The competitive endoge-nous regulation between non-coding RNA(ncRNA)indirectly affects the expression of downstream target genes and is closely related to the malignant biology of GC.Further studies of ncRNA-mediated expression of gastric-cancer-related genes may facilitate early diag-nosis of GC and the search of prognostic markers.This review summarizes the recent discovery of competing endogenous regulation a-mong ncRNA in GC,providing a new approach or strategy for early diagnosis,biomarker development,and application.