Abstract： Aim To investigate the value of clinicopathological features combined with shear wave elastography(SWE)pa-rameters in predicting axillary lymph node metastasis of breast cancer.Methods 72 patients with breast cancer in our hospital re-ceived SWE parameter examinations,ipsilateral axillary lymph node dissection or sentinel lymph node biopsy.According to the oc-currence of axillary lymph node metastasis,33 and 39 cases were divided into metastatic group and non-metastatic group,respectively.The risk factors of axillary lymph node metastasis were analyzed by single factor and multiple factor Logistic analysis.ROC curve was used to evaluate the diagnostic efficacy of clinicopathology combined with SWE in axillary lymph node metastasis.Results The results of univariate analysis showed that there were statistically significant differences in histological grade,lymphovascular invasion,microcalcification,Ki-67,maximum longitudinal diameter of lymph nodes,maximum transverse diameter of lymph nodes,cortical thickness of lymph nodes,average elastic modulus(Emean),maximum elastic modulus(Emax),and standard deviation(SD)between the two groups(P＜0.05).The results of multivariate Logistic regression analysis showed that lymphovascular invasion,histological grade(grade Ⅲ),Emax,and SD were risk factors for axillary lymph node metastasis in breast cancer patients(P＜0.05).ROC re-sults showed that the combined prediction efficiency of grade Ⅲ histology,lymphatic vessel invasion,Emax ≥45.635 kPa,SD≥8.450 was higher than that of each index alone.Conclusion Clinicopathological features combined with SWE parameters have certain predictive value for axillary lymph node metastasis of breast cancer.