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Current status of research and treatment of dry eye associated with chronic ocular graft-versus-host disease

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Author:: No author available

Journal Title:: International Eye Science

Issue:: 12

DOI:: 10.3980/j.issn.1672-5123.2022.12.16

Key Word:: 移植物抗宿主病;眼部移植物抗宿主病;干眼;治疗

Abstract：异基因造血干细胞移植(allo-HSCT)是治疗多种血液系统恶性肿瘤的主要方法,但术后的慢性移植物抗宿主病(cGVHD)是一种常见的并发症,其中眼部移植物抗宿主病(oGVHD)是最常见的一种,主要累及泪腺、睑板腺、角膜和结膜,典型症状为以纤维化为特征的干眼综合征.oGVHD相关干眼导致患者生活质量显著下降,已引起广泛关注.oGVHD的治疗除了应用全身免疫抑制剂和眼润滑剂外,通常联合局部使用糖皮质激素和环孢素.对于中重度oGVHD较新的治疗措施还包括使用自体血清滴眼液和角巩膜接触镜.本文主要就oGVHD及其相关干眼的治疗现状进行综述,以期为临床诊疗提供思路.

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