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Research progress on the roles of transforming growth factor - β in proliferative retinal diseases

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Author:: No author available

Journal Title:: International Eye Science

Issue:: 12

DOI:: 10.3980/j.issn.1672-5123.2022.12.08

Key Word:: 转化生长因子-β(TGF-β);纤维化;增生性玻璃体视网膜病变;增殖期糖尿病视网膜病变;新生血管性年龄相关性黄斑变性

Abstract：转化生长因子-β(TGF-β)是一类具有多重功效的生物因子,参与调控细胞增殖、凋亡、分化,调节机体的免疫功能、炎性反应等.TGF-β信号通路介导的肌成纤维细胞转化与细胞外基质(ECM)过量积累导致视网膜组织收缩和功能受损.各种细胞因子信号参与视网膜组织中的纤维化反应,但TGF-β是影响视网膜纤维化疾病发病最关键的因子.就眼睛而言,角膜混浊、黄斑下纤维化和增殖性视网膜疾病等病理性纤维性疾病导致全世界数以百万计的人视力受损和失明,这仍然是眼科临床需求未得到满足的主要领域之一.故本文主要阐述TGF-β在增殖性视网膜疾病中的发病机制及治疗前景的相关研究进展,以期能为增殖性视网膜疾病的防治提供更多的分子靶点,为新药的研究提供新思路.

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