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Effect of timolol on refractive regression after high myopia surgery at different time points in LASIK operation
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- Author:
- No author available
- Journal Title:
- International Eye Science
- Issue:
- 5
- DOI:
- 10.3980/j.issn.1672-5123.2019.5.27
- Key Word:
- 准分子激光角膜原位磨镶术;噻吗洛尔;高度近视;眼压;屈光回退
Abstract： 目的:观察LASIK术后不同时间应用噻吗洛尔对高度近视患者屈光回退的影响.方法:前瞻性研究.选取2015-08/2016-08收入我院的高度近视患者90例180眼为研究对象,随机分为对照组和观察组,各45例90眼,两组患者术后均常规使用抗生素滴眼液7d,对照组患者于术后第8d开始使用噻吗洛尔滴眼液,观察组患者于术后第1d开始使用噻吗洛尔滴眼液.分别于术前、术后7d,1、3、6mo检测并比较两组患者裸眼视力、等效球镜度、眼压、角膜表面曲率、角膜基质厚度.结果:术后不同时间点两组患者裸眼视力、等效球镜度均有差异(P<0.05),且术后6mo,观察组患者裸眼视力、等效球镜度均优于对照组(0.03±0.01 vs 0.08±0.01;0.15±0.33D vs-0.17±0.36D;均P<0.05).术后不同时间点两组患者角膜基质厚度和角膜表面曲均无组间差异性(P>0.05).术后7d,1、3mo观察组患者眼压均明显低于对照组(均P<0.05),术后6mo两组患者眼压趋于稳定.结论:LASIK术后早期应用噻吗洛尔能有效降低眼压,并保持相对较长时间眼压稳定,阻止角膜膨隆,进而起到预防屈光回退的效果.
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