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Research progress of stem cell-derived RPE cell transplantation therapy for retinal degenerative diseases

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Author:: No author available

Journal Title:: International Eye Science

Issue:: 12

DOI:: 10.3980/j.issn.1672-5123.2017.12.17

Key Word:: 视网膜退行性疾病;年龄相关性黄斑变性;干细胞疗法;视网膜色素上皮;degenerative retinal dieases;age-related macular degeneration;stem cell-based therapy;retinal pigment epithelium

Abstract： ·Age - related macular degeneration ( ARMD ) and Stargardt's macular dystrophy ( SMD ) are two kinds of degenerative retinal diseases that respectively lead to irreversible vision loss of the elderly and juvenile population. However, the severe visual impairment in dry ARMD and SMD remains untreatable. In recent years, with the advancement of stem cell technology, stem cell-derived RPE cell transplantation therapy of retinal degeneration has become new research hotspot and direction. This article reviewed the progress of stem cell based approaches for treating retinal degenerative diseases and discussed the prospect and challenges in this field.

Reference

[1]Alberto, Auricchio,Ivana, Trapani,Rando, Allikmets.Gene Therapy of ABCA4-Associated Diseases.[J].2015,5(5).
[2]Peter, Bracha,Nicholas A, Moore,Thomas A, Ciulla.Induced pluripotent stem cell-based therapy for age-related macular degeneration.[J].2017,17(9).
[3]Yehoshua,Z.,AlexandreDeAmorimGarciaFilho,C.,Nunes,R.P.,etc.Systemic complement inhibition with eculizumab for geographic atrophy in age-related macular degeneration: The COMPLETE study[J].2014,121(3).
[4]Clegg,D.O.,Coffey,P.J.,Pennington,B.O.,etc.Rapid and efficient directed differentiation of human pluripotent stem cells into retinal pigmented epithelium[J].2013,2(5).
[5]Lensch MW,Park IH,Lerou PH,etc.Reprogramming of human somatic cells to pluripotency with defined factors.[J].2008,451(7175).
[6]Kazutoshi, Takahashi,Koji, Tanabe,Mari, Ohnuki,etc.Induction of pluripotent stem cells from adult human fibroblasts by defined factors.[J].2007,131.
[7]Nina, Desai,Pooja, Rambhia,Arsela, Gishto.Human embryonic stem cell cultivation: historical perspective and evolution of xeno-free culture systems.[J].2015,13.
[8]Li,Y.,Tsai,Y.-T.,Hsu,C.-W.,etc.Long-term safety and efficacy of human-induced pluripotent stem cell (iPS) grafts in a preclinical model of retinitis pigmentosa[J].2012,18(9).
[9]Boris V. Stanzel,Zengping Liu,Sudawadee Somboonthanakij,etc.Human RPE Stem Cells Grown into Polarized RPE Monolayers on a Polyester Matrix Are Maintained after Grafting into Rabbit Subretinal Space[J].2014,2(1).
[10]Lu B,Malcuit C,Wang S.Long-term safety and function of RPE from human embryonic stem cells in preclinical models of macular degeneration.[J].2009,27(9).
[11]Lu, Louise J.,Liu, Ji,Adelman, Ron A..Novel therapeutics for Stargardt disease[J].2017,255(6).
[12]Schwartz, Steven D.,Regillo, Carl D.,Lam, Byron L.,etc.Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt's macular dystrophy: follow-up of two open-label phase 1/2 studies[J].2015,385(9967).
[13]J A, Thomson,J, Itskovitz-Eldor,S S, Shapiro,etc.Embryonic stem cell lines derived from human blastocysts.[J].1998,282.
[14]Songstad, Allison E.,Worthington, Kristan S.,Chirco, Kathleen R.,etc.Connective Tissue Growth Factor Promotes Efficient Generation of Human Induced Pluripotent Stem Cell-Derived Choroidal Endothelium[J].2017,6(6).
[15]Tezel TH,Del Priore LV,Kaplan HJ.Reengineering of Aged Bruch's Membrane to Enhance Retinal Pigment Epithelium Repopulation.[J].2004,45(9).
[16]Lyndsay L, Leach,David E, Buchholz,Vignesh P, Nadar,etc.Canonical/β-catenin Wnt pathway activation improves retinal pigmented epithelium derivation from human embryonic stem cells.[J].2015,56.
[17].Developing cellular therapies for retinal degenerative diseases[J].2014,55(2).
[18]Britta, Nommiste,Kate, Fynes,Victoria E, Tovell,etc.Stem cell-derived retinal pigment epithelium transplantation for treatment of retinal disease.[J].2017,231(Spec ).
[19]Zahabi,A.,Shahbazi,E.,Ahmadieh,H.,etc.A new efficient protocol for directed differentiation of retinal pigmented epithelial cells from normal and retinal disease induced pluripotent stem cells[J].2012,21(12).
[20]Heidi, Hongisto,Antti, Jylh?,Janika, N?ttinen,etc.Comparative proteomic analysis of human embryonic stem cell-derived and primary human retinal pigment epithelium.[J].2017,7(1).
[21]Saint-Geniez, Magali,Rosales, Mariana Aparecida B..Eyeing the Fountain of Youth[J].2017,20(5).
[22]Sunao Sugita,Yuko Iwasaki,Kenichi Makabe,etc.Lack of T Cell Response to iPSC-Derived Retinal Pigment Epithelial Cells from HLA Homozygous Donors[J].2016,(4).
[23]Volz, Cornelia,Pauly, Diana.Antibody therapies and their challenges in the treatment of age-related macular degeneration[J].2015,95(Pt.B).
[24]Girman S,Bischoff N,Klimanskaya I,etc.Human embryonic stem cell-derived cells rescue visual function in dystrophic RCS rats[J].2006,8(3).
[25]Carr, Amanda-Jayne,Vugler, Anthony A.,Hikita, Sherry T.,etc.Protective Effects of Human iPS-Derived Retinal Pigment Epithelium Cell Transplantation in the Retinal Dystrophic Rat.[J].2009,4(12).
[26]Sugita, Sunao,Kamao, Hiroyuki,Iwasaki, Yuko,etc.Inhibition of T-Cell Activation by Retinal Pigment Epithelial Cells Derived From Induced Pluripotent Stem Cells[J].2015,56(2).
[27]Graf A,Glittenberg C,Povazay B,etc.Human retinal pigment epithelium (RPE) transplantation: outcome after autologous RPE-choroid sheet and RPE cell-suspension in a randomised clinical study.[J].2011,95(3).
[28]Mark T, Cahill,Prithvi, Mruthyunjaya,Catherine, Bowes Rickman,etc.Recurrence of retinal pigment epithelial changes after macular translocation with 360 degrees peripheral retinectomy for geographic atrophy.[J].2005,123.
[29]Hynes SR,Lavik EB.A tissue-engineered approach towards retinal repair: scaffolds for cell transplantation to the subretinal space.[J].2010,248(6).
[30]Buchholz DE,Hikita ST,Rowland TJ.Derivation of functional retinal pigmented epithelium from induced pluripotent stem cells.[J].2009,27(10).
[31]Pennington, Britney O.,Clegg, Dennis O.,Melkoumian, Zara K.,etc.Defined Culture of Human Embryonic Stem Cells and Xeno-Free Derivation of Retinal Pigmented Epithelial Cells on a Novel, Synthetic Substrate[J].2015,4(2).
[32]Junying, Yu,Maxim A, Vodyanik,Kim, Smuga-Otto,etc.Induced pluripotent stem cell lines derived from human somatic cells.[J].2007,318.
[33]Croze,R.H.,Buchholz,D.E.,Radeke,M.J.,etc.ROCK inhibition extends passage of pluripotent stem cell-derived retinal pigmented epithelium[J].2014,3(9).
[34]Schwartz,S.D.,Hubschman,J.-P.,Heilwell,G.,etc.Embryonic stem cell trials for macular degeneration: A preliminary report[J].2012,379(9817).
[35]Mandai, M.,Watanabe, A.,Kurimoto, Y.,etc.Autologous Induced Stem-Cell-Derived Retinal Cells for Macular Degeneration[J].2017,376(11).
[36]Calejo, Maria Teresa,Ilmarinen, Tanja,Vuorimaa-Laukkanen, Elina,etc.Langmuir-Schaefer film deposition onto honeycomb porous films for retinal tissue engineering[J].2017,54.
[37]Garg, Aakriti,Jin Yang,Lee, Winston,etc.Stem Cell Therapies in Retinal Disorders.[J].2017,6(1).
[38]Sasai Y,Kitada M,Takahashi M,etc.In vitro and in vivo characterization of pigment epithelial cells differentiated from primate embryonic stem cells.[J].2004,45(3).