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蛋白激酶C在急性肺损伤/急性呼吸窘迫综合征中作用的研究进展

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Author:: No author available

Journal Title:: Chinese Journal of Emergency Medicine

Issue:: 4

DOI:: 10.3760/cma.j.issn.1671-0282.2018.04.024

Key Word:: No keyword available

Abstract：急性肺损伤(acute lung injury,ALI)主要发病机制是多种肺内/肺外因素引起的急性炎症反应破坏了肺泡-血管内皮屏障,导致富含蛋白质和炎症细胞的液体渗出到肺泡与肺间质形成了弥漫性肺水肿[1].ALI起病急,进展速度快,预后差,严重者可致急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS),病死率高达41.9％～ 50.4％[2].目前,针对ALI/ARDS的治疗主要是通过机械通气、液体管理和抗炎等方式,尚无特效的药物治疗方法,主要原因是由于ALI/ARDS的发病机制尚未完全明确[3].

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