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An experimental study of chitosan in the treatment and prevention of adhesions in acute peritonitis
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- Author:
- No author available
- Journal Title:
- JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 4
- DOI:
- 10.3760/j.issn:1671-0282.2002.04.008
- Key Word:
- 几丁聚糖;腹膜炎;肠粘连;治疗;预防
Abstract： 目的研究几丁聚糖对大鼠急性腹膜炎的治疗和术后肠粘连的预防作用.方法 4个月龄大鼠200只制成急性腹膜炎和肠粘连动物模型.用1%的几丁聚糖作腹腔灌注,以生理盐水、1%醋酸和甲硝唑分别作对照,观察大鼠的死亡率、两周后存活动物的肠粘连程度和血清可溶性白细胞介素-2受体水平.结果几丁聚糖显著降低大鼠的死亡率和粘连等级(P＜0.05).在不同时间血清可溶性白细胞介素-2受体显著低于各对照组(P＜0.05).结论 1%几丁聚糖对治疗急性腹膜炎和预防肠粘连有显著的作用.
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