You Position: Home > Paper
The comparison of the effect of perdipine on blood pressure reduction around anesthesia induction with urapidil for patients with cerebral hemorrhage due to hypertension
( views:365, downloads:32 )
- Author:
- No author available
- Journal Title:
- JOURNAL OF EMERGENCY MEDICINE
- Issue:
- 1
- DOI:
- 10.3760/j.issn:1671-0282.2000.01.007
- Key Word:
- 高血压;脑出血;佩尔地平;压宁定
Abstract： 目的:比较佩尔地平和压宁定在高血压脑出血急诊开颅术麻醉诱导期降压作用.方法:45例高血压脑出血,急诊开颅血肿清除术病例随机分成2组:A组15例,诱导前5min静脉注射佩尔地平30ug/kg,观察给药后第1、3、5min,诱导后第3min,插管即刻,插管后第1、3、5min的收缩压、舒张压、平均动脉压、心率的变化;B组30例,同期注射压宁定0.5mg/kg,观察各项参数.结果:各组降压效果显著,和术前比较P＜0.05或P＜0.01,但常规剂量下A组降压效果显著强于B组;A组心率和术前比较显著加快,B组心率无改变.结论:对于高血压导致的急性脑出血患者,在麻醉诱导期前后,佩尔地平和压宁定均能显著地降低血压,在常规剂量下前者作用显著强于后者;佩尔地平有显著加快心率的作用,但压宁定不加快心率.
- [1]D S, Warner,M D, Sokoll,M, Maktabi,etc.Nicardipine HCl: clinical experience in patients undergoing anaesthesia for intracranial aneurysm clipping.[J].1989,36(2).
- [2]P, Bousquet,J, Feldman,J, Schwartz.On the mechanism of the hypotensive action of urapidil.[J].1985,3(3).
- [3]K, Mikawa,H, Obara,M, Kusunoki.Effect of nicardipine on the cardiovascular response to tracheal intubation.[J].1990,64.
- [4]J A, Kaplan.Clinical considerations for the use of intravenous nicardipine in the treatment of postoperative hypertension.[J].1990,119.
- [5]王义军,廖大成.压宁定降压应用于动脉导管未闭结扎手术中的临床研究[J].1995,015 (3).