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Ferroptosis-related mRNAs signature predicts prognosis of gastric cancer

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Author:: No author available

Journal Title:: World Chinese Journal of Digestology

Issue:: 24

DOI:: 10.11569/wcjd.v29.i24.1410

Key Word:: 胃癌;铁死亡;预后;mRNA

Abstract：背景胃癌是常见的消化道肿瘤,其预后较差.铁死亡是一种新型的调节细胞死亡形式,在肿瘤发生中起关键作用.因此构建铁死亡相关基因预后模型并预测胃癌的预后及相关治疗靶点是有意义的.目的探讨铁死亡相关基因在胃癌中的潜在预后价值.方法铁死亡是一种脂质的铁依赖性过氧化作用驱动细胞死亡类型,基于胃癌铁死亡相关差异表达基因构建预后模型.结果确定4种与胃癌预后相关的不同表达的mRNAs(DUSP1、MYB、CAV1、NOX4).Kaplan-Meier分析显示高危组与胃癌预后不良相关,且风险评分是生存的独立预后指标.制作预后模型显示在预测胃癌预后方面优于传统的临床病理学特征.此外,低危组和高危组在免疫细胞浸润与免疫检查点等方面之间存在显著差异.结论铁死亡相关mRNAs特征可以预测胃癌的预后并提供治疗靶点.

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