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Long non-coding RNAs as potential markers for occurrence,progression, and prognosis of gastric cancer

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Author:: No author available

Journal Title:: World Chinese Journal of Digestology

Issue:: 13

DOI:: 10.11569/wcjd.v28.i13.544

Key Word:: 长链非编码RNA;胃癌;进展;预后;耐药性

Abstract：近年来,长链非编码RNA (long non-coding RNA,lncRNA)与肿瘤的关系受到越来越多的关注,lncRNA的异常表达通过参与胃癌(gastric cancer, GC)细胞增殖、侵袭、迁移等生物学行为,在GC发生中发挥着致癌/抑癌基因的作用.本文通过总结相关文献,对lncRNA的研究现状、检测技术、在GC发生、进展、预后及耐药相关潜在标志物的作用机制进行分析,以期lncRNA能作为GC靶基因在早期发现、早期治疗、有效改善化疗耐药中发挥重要作用,提高患者生存质量,达到GC临床个体化精准治疗.

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