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Prognostic implications of preoperative platelet count to maximum tumor diameter ratio for colorectal cancer

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Author:: No author available

Journal Title:: World Chinese Journal of Digestology

Issue:: 1

DOI:: 10.11569/wcjd.v28.i1.26

Key Word:: 结直肠癌;血小板计数;肿瘤最大径;无进展生存期;比值;预后

Abstract：背景术前血小板计数,肿瘤最大径可辅助判断结直肠癌(colorectal cancer,CRC)患者预后,结合两者可在一定程度上取长补短,准确判断患者预后.但目前在临床上,对于联合这两个参数,如血小板计数和肿瘤最大径比(platelet count and maximum tumor diameter ratio,PTR)是否可存在价值的报道较少.目的探讨术前PTR对CRC患者3年无进展生存期(progression free survival,PFS)的预测价值.方法收集解放军总医院海南医院自2012-12/2019-06经手术后病理确诊的结直肠腺癌患者127例,计算PTR并分析其在性别、年龄等不同临床临床参数中的差异和对PFS预测的价值.结果 (1)PTR对患者3年PFS存在一定价值(AUC=0.66,95％CI:0.56-0.76,P＜0.01),当其取值为57.27时,其对3年PFS预测的敏感性73.30％,特异性为56.10％;(2)以57.27为界,PTR高于界值的患者预后较好(Log-rank=9.70,P＜0.01),生存时间明显长于低于界值的患者(50.02 mo±22.33 mo vs 38.46 mo±24.39 mo,t=-2.76,P＜0.01);(3)单因素分析显示术前癌胚抗原、糖类抗原199及TNM分期,PTR对患者生存存在影响(P＜0.01),但多因素分析仅显示术前癌胚抗原、N及M分期是独立预测因子.结论 PTR对CRC患者3年PFS预测存在一定价值,其中PTR较高的患者生存相对较好,但PTR不是患者预后的独立预测因子.

Reference

[1]游俊浩,崔美琦,颜兵.术前血小板计数和肿瘤最大径比对非转移性胃癌患者的预后作用[J].2019,(2).
[2]Costa, S. D.,Ignatov, A.,Eggemann, H.,etc.Platelet Count After Chemotherapy is a Predictor for Outcome for Ovarian Cancer Patients[J].2015,33.
[3]Shaogui, Wan,Yinzhi, Lai,Ronald E, Myers,etc.Preoperative platelet count associates with survival and distant metastasis in surgically resected colorectal cancer patients.[J].2013,44(3).
[4]Yu, Long,Ting, Wang,Qian, Gao,etc.Prognostic significance of pretreatment elevated platelet count in patients with colorectal cancer: a meta-analysis.[J].2016,(49).
[5]Lola-Jade Palmieri,Amina Fihri,Solène Doat,etc.Tumor-size responses to first-line is a predictor of overall survival in metastatic colorectal cancer[J].2019,29(7).
[6]Mei-Ling, Gu,Cai-Jun, Yuan,Xiao-Mei, Liu,etc.Pre-treatment Elevated Platelet Count Associates with HER2 Overexpression and Prognosis in Patients with Breast Cancer.[J].2015,16.
[7]Wanqing, Chen,Rongshou, Zheng,Peter D, Baade,etc.Cancer statistics in China, 2015.[J].1900,66.
[8]Yu, Dangfan,Liu, Bingjiang,Zhang, Lizhen,etc.Platelet count predicts prognosis in operable non-small cell lung cancer[J].2013,5(5).
[9]Hatzopoulos A,Kritikos K,Heras P,etc.Platelet count and tumor progression in gastric cancer patients.[J].2010,45(7).
[10]Corrado, Pedrazzani,Guido, Mantovani,Eduardo, Fernandes,etc.Assessment of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and platelet count as predictors of long-term outcome after R0 resection for colorectal cancer.[J].2017,7(1).
[11]Hiroaki, Saito,Yusuke, Kono,Yuki, Murakami,etc.Prognostic Significance of Platelet-Based Inflammatory Indicators in Patients with Gastric Cancer.[J].2018,(Spec ).
[12]Sung Eun Oh,Jeong Eun Seo,Ji Yeong An,etc.Prognostic Impact of Increased Perioperative Platelet Count in Gastric Cancer Patients[J].2019,242.
[13].Prognostic effect of red cell distribution width-to-platelet ratio in colorectal cancer according to tumor stage and localization.[J].2019,15(1).
[14]Santullo, Francesco,Biondi, Alberto,Cananzi, Ferdinando C. M.,etc.Tumor size as a prognostic factor in patients with stage IIa colon cancer[J].2018,215(1).
[15]Qingying,Yan,Kai,Zhang,Kaibo,Guo,etc.Value of tumor size as a prognostic factor in metastatic colorectal cancer patients after chemotherapy: a population-based study.[J].2019.
[16]Grothey A,Galanis E.Targeting angiogenesis: progress with anti-VEGF treatment with large molecules.[J].2009,6(9).
[17]Lin,M.S.,Huang,J.X.,Shen,H.Z.,etc.Elevation of platelet count in patients with colorectal cancer predicts tendency to metastases and poor prognosis[J].2012,59(118).
[18]N. M. BAMBACE,C. E. HOLMES.The platelet contribution to cancer progression[J].2010,9(2).
[19]Kimberly M. Brown,Christinnah Domin,Gerard V. Aranha,etc.Increased preoperative platelet count is associated with decreased survival after resection for adenocarcinoma of the pancreas[J].2005,189(3).