Paper - WANFANG MED ONLINE

You Position: Home > Paper

Mechanism of autophagy in liver fibrosis

( views:69, downloads:0 )

Author:: No author available

Journal Title:: World Chinese Journal of Digestology

Issue:: 23

DOI:: 10.11569/wcjd.v26.i23.1415

Key Word:: 自噬;肝纤维化;信号通路

Abstract：自噬是细胞依赖溶酶体的一种代谢过程,通过分解细胞内蛋白质、脂质等成分,循环再利用分解产物,使细胞适应不利的生活环境,是机体维持内环境稳态的重要机制.肝纤维化是指肝组织内细胞外基质成分过度增生与异常沉积,导致肝脏结构和功能异常的病理变化,肝纤维化见于多数不同病因的慢性肝脏疾病中.本文总结了自噬参与肝纤维化的作用以及与肝纤维化相关的自噬信号通路,进一步阐述细胞自噬参与肝纤维化的机制.

Reference

[1]Yulong L, Chen,Ping-Y, Law,Horace H, Loh.Inhibition of PI3K/Akt signaling: an emerging paradigm for targeted cancer therapy.[J].2005,5(6).
[2]Xiao-Ming, Meng,David J, Nikolic-Paterson,Hui Yao, Lan.TGF-β: the master regulator of fibrosis.[J].2016.
[3]Li,J.,Yang,B.,Zhou,Q.,etc.Autophagy promotes hepatocellular carcinoma cell invasion through activation of epithelial-mesenchymal transition[J].2013,34(6).
[4]Wands,J.R.,Kim,M..WNT/β-catenin signaling and hepatocellular carcinoma[J].2014,60(2).
[5]Xiaohong, Li,Shaojie, Yue,Ziqiang, Luo.Mesenchymal stem cells in idiopathic pulmonary fibrosis.[J].2017,(Spec ).
[6]Y C, Yeh,J F, Tsai,L Y, Chuang,etc.Elevation of transforming growth factor alpha and its relationship to the epidermal growth factor and alpha-fetoprotein levels in patients with hepatocellular carcinoma.[J].1987,47.
[7]Wafa, B'chir,Anne-Catherine, Maurin,Valérie, Carraro,etc.The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression.[J].2013,41(16).
[8]Shin,J.Y.,Park,H.J.,Kim,H.N.,etc.Mesenchymal stem cells enhance autophagy and increase β-amyloid clearance in Alzheimer disease models[J].2014,10(1).
[9]Ying, Qu,Qidi, Zhang,Xiaobo, Cai,etc.Exosomes derived from miR-181-5p-modified adipose-derived mesenchymal stem cells prevent liver fibrosis via autophagy activation.[J].2017,(Spec ).
[10]Nakanuma Y,Sato Y,Miyakoshi M,etc.Epidermal growth factor induces cytokeratin 19 expression accompanied by increased growth abilities in human hepatocellular carcinoma.[J].2011,91(2).
[11]Masao Yamada,William S. Blaner,Dianne Robert Soprano,etc.Biochemical characteristics of isolated rat liver stellate cells[J].1987,7(6).
[12]Dongdong, Chen,Xiaoxiao, Wu,Jie, Zheng,etc.Autophagy regulates proliferation and biliary differentiation of hepatic oval cells via the MAPK/ERK signaling pathway.[J].2018,17(2).
[13]Hernández-Gea,V.,Friedman,S.L..Autophagy fuels tissue fibrogenesis[J].2012,8(5).
[14]Thoen LF,Guimaraes EL,Dolle L,etc.A role for autophagy during hepatic stellate cell activation.[J].2011,55(6).
[15]Song G,Ouyang G,Bao S.The activation of Akt/PKB signaling pathway and cell survival.[J].2005,9(1).
[16]Nicole, Testerink,Mokrish, Ajat,Martin, Houweling,etc.Replacement of retinyl esters by polyunsaturated triacylglycerol species in lipid droplets of hepatic stellate cells during activation.[J].2012,7(4).
[17]Miao, Shen,Kan, Chen,Jie, Lu,etc.Protective effect of astaxanthin on liver fibrosis through modulation of TGF-β1 expression and autophagy.[J].2014,2014.
[18]Yoshinori Ohsumi.Historical landmarks of autophagy research[J].2014,(1).
[19]Rzymski T,Milani M,Singleton DC,etc.Role of ATF4 in regulation of autophagy and resistance to drugs and hypoxia.[J].2009,8(23).
[20]Hayam G, Sayyed,Amany, Osama,Naglaa K, Idriss,etc.Comparison of the therapeutic effectiveness of human CD34+ and rat bone marrow mesenchymal stem cells on improvement of experimental liver fibrosis in Wistar rats.[J].2016,(3).
[21]Xu, Bei,Lin, Lanyi,Xu, Guoguang,etc.Long-term lamivudine treatment achieves regression of advanced liver fibrosis/cirrhosis in patients with chronic hepatitis B[J].2015,30(2).
[22]Lian, Liu,Jia-Zhi, Liao,Xing-Xing, He,etc.The role of autophagy in hepatocellular carcinoma: friend or foe.[J].2017,(Spec ).
[23]Prescott, Mark,Devenish, Rodney J.,Gong, Lan.Autophagy as a macrophage response to bacterial infection[J].2012,64(9).
[24]Liwei, Wu,Qinghui, Zhang,Wenhui, Mo,etc.Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-β1/Smads and PI3K/Akt pathways.[J].2017,7(1).
[25]Kumar, Sanjay,Shah, Nirav,Bloodworth, Jeffrey C.,etc.Endoglin Regulation of Smad2 Function Mediates Beclin1 Expression and Endothelial Autophagy[J].2015,290(24).
[26]Suryakant, Niture,Malathi, Ramalinga,Habib, Kedir,etc.TNFAIP8 promotes prostate cancer cell survival by inducing autophagy.[J].2018,9(42).
[27]Katsunori, Yoshida,Koichi, Matsuzaki,Miki, Murata,etc.Clinico-Pathological Importance of TGF-β/Phospho-Smad Signaling during Human Hepatic Fibrocarcinogenesis.[J].2018,10(6).
[28]Hamacher Brady A,Brady NR,Gottlieb RA.Enhancing macroautophagy protects against ischemia/reperfusion injury in cardiac myocytes.[J].2006,281(40).
[29]Mu,R.,Hu,Z.-W.,Wang,W.,etc.DEDD interacts with PI3KC3 to activate autophagy and attenuate epithelial-mesenchymal transition in human breast cancer[J].2012,72(13).
[30]Tang, Hao,Li, Rong-Ping,Liang, Ping,etc.miR-125a inhibits the migration and invasion of liver cancer cells via suppression of the PI3K/AKT/mTOR signaling pathway[J].2015,10(2).
[31]Hara T,Nakamura K,Matsui M,etc.Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice[J].2006,441(7095).
[32]Liang Liu,Xian Jin,Cui-Fen Hu,etc.Exosomes Derived from Mesenchymal Stem Cells Rescue Myocardial Ischaemia/Reperfusion Injury by Inducing Cardiomyocyte Autophagy Via AMPK and Akt Pathways.[J].2017,43(1).
[33]T P, ASHFORD,K R, PORTER.Cytoplasmic components in hepatic cell lysosomes.[J].1962,12.
[34]Shiota G,Kawasaki H,Harada K.Transforming growth factor-alpha and epidermal growth factor receptor in chronic liver disease and hepatocellular carcinoma.[J].1999,19(4).
[35]Y, Inagaki,I, Okazaki.Emerging insights into Transforming growth factor beta Smad signal in hepatic fibrogenesis.[J].2007,56(2).
[36]Y, Ito,T, Takeda,S, Higashiyama,etc.Expression of heparin binding epidermal growth factor-like growth factor in hepatocellular carcinoma: an immunohistochemical study.[J].1900,8.
[37]Nunzia, Pastore,Keith, Blomenkamp,Fabio, Annunziata,etc.Gene transfer of master autophagy regulator TFEB results in clearance of toxic protein and correction of hepatic disease in alpha-1-anti-trypsin deficiency.[J].2013,5(3).
[38]Li,T.,Zhu,W.,Shen,L.,etc.Exosomes derived from human umbilical cord mesenchymal stem cells alleviate liver fibrosis[J].2013,22(6).
[39]Minhwa, Park,Yu-Hee, Kim,So-Youn, Woo,etc.Tonsil-derived mesenchymal stem cells ameliorate CCl4-induced liver fibrosis in mice via autophagy activation.[J].2015,5.
[40]Jingjing, Li,Kan, Chen,Sainan, Li,etc.Protective effect of fucoidan from Fucus vesiculosus on liver fibrosis via the TGF-β1/Smad pathway-mediated inhibition of extracellular matrix and autophagy.[J].2016.
[41]Khramtsov AI,Khramtsova GF,Tretiakova M,etc.Wnt/beta-catenin pathway activation is enriched in basal-like breast cancers and predicts poor outcome.[J].2010,176(6).
[42]Kaushik, Susmita,Cuervo, Ana Maria.Chaperone-mediated autophagy: a unique way to enter the lysosome world[J].2012,22(8).
[43]Yamaguchi,O.,Otsu,K..Role of autophagy in aging[J].2012,60(3).
[44]Du, Chao,Wang, Yunxia,Qin, Jianpin,etc.Transplantation of human matrix metalloproteinase-1 gene-modified bone marrow-derived mesenchymal stem cell attenuates CCL4-induced liver fibrosis in rats[J].2018,41(6).
[45]Tong, Liu,Ling, Xu,Chengfen, Wang,etc.Shikonin alleviates hepatic fibrosis and autophagy via inhibition of TGF-β1/Smads pathway.[J].2018,(Spec ).