Abstract: Evidence-based medicine (EBM) is a scientific approach to help doctors to make right care decisions based on research evidence integrating clinical state andcircumstance as well as patient's preference and actions. At present, EBM has been abused and misunderstood in some cases. In this paper, I discuss the evolution of the concept of EBM, the relationship between translational medicine and precision medicine, and the debate on EBM, with an aim to help doctors correctly understand EBM and use EBM methods to make right care decisions.