Abstract： AIM To observe the clinical effects of taursodeoxycholic acid combined with S-adenosyl methionine in the treatment of cholestasis in patients with compensated alcoholic cirrhosis.METHODS One hundred patients withcompensated alcoholic cirrhosis treated at our hospital from January 2012 to January 2017 were randomly divided into an experimental group and a control group,with 50 cases in each group.Both groups of patients were given S-adenosyl methionine and hepatoProtective drugs,and the experimental group was additionally given tauroursodeoxycholic acid.After 12.wk of treatment,the changes of liver biochemical indicators [alkaline phosphatase (ALP),gamma glutamyl transaminase (GGT),and total bilirubin (TBIL)] and prothrombin activity (PTA) were detected to evaluate the therapeutic effect.RESULTS The total effective rate in the experimental group was significantly higher than that of the control group (92％ vs 56％,P ＜ 0.05).After treatmernt,ALP,GGT and TBIL in both groups decreased significantly compared with pretreatment values (P ＜ 0.05),and the thereapeutic effect in the experimental group was better than that in the control group (P ＜ 0.05).CONCLUSION Tauroursodeoxycholic acid combined with S-adenosyl methionine is effective in treating cholestasis in patients with compensated alcoholic cirrhosis,and can effectively improve the clinical symptoms and biochemical indexes.