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Effect of mode of acinar cell death on acute pancreatitis

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Author:: No author available

Journal Title:: World Chinese Journal of Digestology

Issue:: 34

DOI:: 10.11569/wcjd.v25.i34.3067

Key Word:: 腺泡细胞;死亡方式;急性胰腺炎;Acinar cell;Death modality;Acute pancreatitis

Abstract： Acinar cell death is the most important pathophysiological change in the early stage of acute pancreatitis,and it has been the emphasis of the research.The mode of acinar cell death includes apoptosis,necrosis,necroptosis,autophagy,and pyroptosis.Some scholars have shown that acinar cell death affects the outcome of acute pancreatitis.Therefore,studying the mode of acinar cell death has great value in the assessment of the severity of acute pancreatitis.Apoptosis can reduce inflammatory response,and necrosis aggravates inflammatory response.In recent years,research on the effect of necroptosis and pyroptosis on acute pancreatitis has been carried out.This article will review the effect of apoptosis,necrosis,necroptosis,and pyroptosis on acute pancreatitis.

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