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Imbalance of intestinal flora:A new target for nonalcoholic fatty liver disease treatment

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Author:: No author available

Journal Title:: World Chinese Journal of Digestology

Issue:: 22

DOI:: 10.11569/wcjd.v25.i22.2000

Key Word:: 非酒精性脂肪肝病;肠道菌群;能量代谢;脂质蓄积;炎症反应;Non-alcoholic fatty liver disease;Intestinal flora;Energy metabolism;Lipid accumulation;Inflammation

Abstract： Non-alcoholic fatty liver disease (NAFLD) is a clinical pathologic syndrome characterized by steatosis and storage of hepatic parenchymal cells due to liver damage caused by factors other than alcohol.In recent years,with the change of people's lifestyle,NAFLD has become a global public health problem.The incidence of NAFLD is associated with obesity,type-2 diabetes and other metabolic syndromes.More and more studies indicate that intestinal flora is closely related with the occurrence and development of NAFLD:(1) Intestinal flora can promote the energy metabolism of the host;(2) Intestinal flora can induce the body lipid metabolism disorders and liver cell lipid accumulation;and (3) Intestinal flora can increase the intestinal mucosal permeability and activate inflammation.This article summarizes the relationship between NAFLD and intestinal flora imbalance,which may be a new target for NAFLD treatment.

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