Paper - WANFANG MED ONLINE

You Position: Home > Paper

Regulation of intracellular zinc homeostasis: Role in occurrence and development of pancreatic carcinoma

( views:17, downloads:0 )

Author:: No author available

Journal Title:: World Chinese Journal of Digestology

Issue:: 18

DOI:: 10.11569/wcjd.v25.i18.1615

Key Word:: 胰腺癌;细胞内锌稳态;调控;金属硫蛋白;金属转录因子1;Pancreatic carcinoma;Intracellular zinc homeostasis;Regulation;Metallothionein;Metal regulatory transcription factor 1

Abstract： Zinc (Zn) is an essential micronutrient that is required in over 300 different cellular processes,including DNA and protein synthesis,enzyme activity,and intracellular signaling.Zn availability is also important for tumor growth and progression because it is an essential component for many enzymes such as carbonic anhydrase and matrix metalloproteinases,which are involved in hypoxia,angiogenesis,cell proliferation,and metastasis.Intracellular Zn homeostasis is tightly regulated through the integration of Zn transporting mechanisms,including zinc influx,efflux and intracellular retention.A large number of studies have confirmed that the deregulation of Zn homeostasis is related to the occurrence and metastasis of pancreatic carcinoma.Therefore,the abnormal regulation of intracellular zinc homeostasis plays an important role in the occurrence and development of pancreatic carcinoma.

Reference

[1]Kiziler AR,Titiz I,Dogan M,etc.Serum free prostate-specific antigen and zinc levels in experimental acute pancreatitis.[J].2005,106(3).
[2]Chiara, Murgia,Isabella, Vespignani,Rita, Rami,etc.The Znt4 mutation inlethal milk mice affects intestinal zinc homeostasis through the expression of other Zn transporters.[J].2006,1(1).
[3]B J, Mills,W L, Broghamer,P J, Higgins,etc.Inhibition of tumor growth by zinc depletion of rats.[J].1984,114.
[4]Syrjanen S,Shen Q,Tripod-S A,etc.Cytokeratin expression patterns as an indicator of tumour progression in oesophageal squamous cell carcinoma.[J].2001,21(6A).
[5]Hedy Lee Kindler.Front-Line Therapy of Advanced Pancreatic Cancer[J].2005,32(1).
[6]Tang-.Zinc has an insulin-like effect on glucose transport mediated by phosphoinositol-3-kinase and Akt in 3T3-L1 fibroblasts and adipocytes.[J].2001,131(5).
[7]Jér?me, Torrisani,Louis, Buscail.[Molecular pathways of pancreatic carcinogenesis].[J].2002,22(5).
[8]Dufner Beattie J,Kuo YM,Gitschier J,etc.The acrodermatitis enteropathica gene ZIP4 encodes a tissue-specific, zinc-regulated zinc transporter in mice.[J].2003,278(35).
[9]W, DeWys,W, Pories.Inhibition of a spectrum of animal tumors by dietary zinc deficiency.[J].1972,48(2).
[10]Cui,X.,Zhang,Y.,Yang,J.,etc.ZIP4 confers resistance to zinc deficiency-induced apoptosis in pancreatic cancer[J].2014,13(7).
[11]Yu X,Zhang Y,Chen.Targeted drug delivery in pancreatic cancer.[J].2010,1805(1).
[12]Zhihui Tang,Surasri Nandan Sahu,Mohammed Abdul Khadeer,etc.Overexpression of the ZIP1 zinc transporter induces an osteogenic phenotype in mesenchymal stem cells[J].2006,38(2).
[13]Yin D,Fink AK,Stewart SL,etc.The accuracy of cancer mortality statistics based on death certificates in the United States.[J].2011,35(2).
[14]Kim BE,Petris MJ,Wang F,etc.A histidine-rich cluster mediates the ubiquitination and degradation of the human zinc transporter, hZIP4, and protects against zinc cytotoxicity.[J].2007,282(10).
[15]Eide DJ.Zinc transporters and the cellular trafficking of zinc[J].2006,1763(7).
[16]Fontaine, Charles P.,Holmes, William R.,Maret, Wolfgang,etc.Cytosolic zinc buffering and muffling: Their role in intracellular zinc homeostasis[J].2010,2(5).
[17]J T, McQuitty,W D, DeWys,L, Monaco,etc.Inhibition of tumor growth by dietary zinc deficiency.[J].1970,30.
[18]Krzysztof, Bojarski,Andrzej, Dabrowski,Grzegorz, Wallner,etc.Shift of zinc in serum and tissues in course of experimental acute pancreatitis.[J].2002,57(2).
[19]Choi DW,Tian M,Cousins RJ,etc.L-type Ca(2+) channel-mediated Zn(2+) toxicity and modulation by ZnT-1 in PC12 cells.[J].2000,886(1).
[20]Laura M, Plum,Lothar, Rink,Hajo, Haase.The essential toxin: impact of zinc on human health.[J].2010,7(4).
[21]Min, Li,Yuqing, Zhang,Uddalak, Bharadwaj,etc.Down-regulation of ZIP4 by RNA interference inhibits pancreatic cancer growth and increases the survival of nude mice with pancreatic cancer xenografts.[J].2009,15.
[22]A, Takeda,K, Goto,S, Okada.Zinc depletion suppresses tumor growth in mice.[J].1997,59(1-3).
[23]Narita H,Yamaguchi Iwai Y,Iwanaga T,etc.Cloning and characterization of a novel mammalian zinc transporter, zinc transporter 5, abundantly expressed in pancreatic beta cells.[J].2002,277(21).
[24]John K. Chesters,Ronald Boyne.Nature of the Zn2+ requirement for DNA synthesis by 3T3 cells[J].1991,192(2).
[25]Slucca M,Harmon JS,Oseid E.ATP-sensitive K+ channel mediates the zinc switch-off signal for glucagon response during glucose deprivation.[J].2010,59(1).
[26]Dai FF,Lu H,Lee SC,etc.Investigation of Transport Mechanisms and Regulation of Intracellular Zn2+ in Pancreatic {alpha}-Cells.[J].2008,283(15).
[27]Lichten, LA,Wang, FD,Cousins, RJ,etc.STAT5-glucocorticoid receptor interaction and MTF-1 regulate the expression of ZnT2 (Slc30a2) in pancreatic acinar cells[J].2010,107(7).
[28]Prasad AS,Snell DC,Beck FW,etc.Zinc in cancer prevention.[J].2009,61(6).
[29]Li D,Xie K,Wolff R,etc.Pancreatic cancer.[J].2004,363(9414).
[30]Zhang Q,Rorsman P,Shigeto M,etc.Membrane potential-dependent inactivation of voltage-gated ion channels in alpha-cells inhibits glucagon secretion from human islets.[J].2010,59(9).
[31]Scott HM,Lienhard GE,Mastick CC,etc.Cloning and characterization of a novel insulin-regulated membrane aminopeptidase from Glut4 vesicles.[J].1995,270(40).
[32]Canfield Wesley K.,Hambidge K. Michael,Johnson LuAnn K..Zinc Nutriture in Type I Diabetes Mellitus[J].1984.
[33]Mary Lou Guerinot.The ZIP family of metal transporters[J].2000,1465(1).
[34]Duminy H,Wu B,Kummer A,etc.Zinc accumulation in N-methyl-N-nitrosourea-induced rat mammary tumors is accompanied by an altered expression of ZnT-1 and metallothionein.[J].2003,228(6).
[35]Philipps AF.A Graded Model of Dietary Zinc Deficiency: Effects on Growth, Insulin-Like Growth Factor-I, and the Glucose/Insulin Axis in Weanling Rats.[J].2005,41(1).
[36]Liuzzi, J P,Cousins, R J.Mammalian zinc transporters.[J].2004,24.
[37]Liuzzi JP,Zhang S,Li M,etc.Aberrant expression of zinc transporter ZIP4 (SLC39A4) significantly contributes to human pancreatic cancer pathogenesis and progression[J].2007,104(47).
[38]Kim BE,Dufner Beattie J,Eide DJ,etc.Zn2+-stimulated endocytosis of the mZIP4 zinc transporter regulates its location at the plasma membrane.[J].2004,279(6).
[39]Louise Y Y, Fong,David J, Feith,Anthony E, Pegg.Antizyme overexpression in transgenic mice reduces cell proliferation, increases apoptosis, and reduces N-nitrosomethylbenzylamine-induced forestomach carcinogenesis.[J].2003,63(14).
[40]W, DeWys,W J, Pories,M C, Richter,etc.Inhibition of Walker 256 carcinosarcoma growth of dietary zinc deficiency.[J].1970,135.
[41]Stephanie A, Navarro Silvera,Thomas E, Rohan.Trace elements and cancer risk: a review of the epidemiologic evidence.[J].2007,18(1).
[42]Eide DJ.The SLC39 family of metal ion transporters.[J].2004,447(5).
[43]Banavara Narasimhamurthy, Girish,Gopalakrishna, Rajesh,Kannan, Vaidyanathan,etc.Zinc status in chronic pancreatitis and its relationship with exocrine and endocrine insufficiency.[J].2009,10(6).
[44]Louise Y Y, Fong,Rita, Mancini,Hiroshi, Nakagawa,etc.Combined cyclin D1 overexpression and zinc deficiency disrupts cell cycle and accelerates mouse forestomach carcinogenesis.[J].2003,63.
[45]Yuqing, Zhang,Jingxuan, Yang,Xiaobo, Cui,etc.A novel epigenetic CREB-miR-373 axis mediates ZIP4-induced pancreatic cancer growth.[J].2013,5(9).
[46]Keller SR.Role of the Insulin-Regulated Aminopeptidase IRAP in Insulin Action and Diabetes.[J].2004,27(6).
[47]A M, Huber,S N, Gershoff.Effect of zinc deficiency in rats on insulin release from the pancreas.[J].1973,103(12).
[48]Kun Wang,Bing Zhou,Yien-Ming Kuo,etc.A Novel Member of a Zinc Transporter Family Is Defective in Acrodermatitis Enteropathica[J].2002,71(1).
[49]Dufner Beattie J,Langmade SJ,Wang F,etc.Structure, function, and regulation of a subfamily of mouse zinc transporter genes.[J].2003,278(50).
[50]Zhang Y,Bharadwaj U,Logsdon C.ZIP4 regulates pancreatic cancer cell growth by activating IL-6/STAT3 pathway through zinc finger transcription factor CREB.[J].2010,16(5).
[51]Ellison LF.Measuring the effect of including multiple cancers in survival analyses using data from the Canadian Cancer Registry.[J].2010,34(5).
[52]Philipps AF,Lonnerdal B,Jou MY.Maternal zinc deficiency in rats affects growth and glucose metabolism in the offspring by inducing insulin resistance postnatally.[J].2010,140(9).
[53]Koh JY,Lee MK,Kim S,etc.Zinc as a paracrine effector in pancreatic islet cell death.[J].2000,49(3).