Abstract： AIM To observe the curative effect of Weifuchun combined with quadruple therapy for Helicobacter pylori (H.pylori)-related chronic non-atrophic gastritis.METHODS A total of 196 chronic non-atrophic gastritis patients who tested positive for H.pylori were randomly divided into either a control group (n =97;quadruple therapy alone) or a treatment group (n =99;Weifuchun combined with quadruple therapy).The H.pylori eradication rates,gastroscopic and clinical curative effects were compared between the two groups.RESULTS The H.pylori eradication rate,gastroscopic and symptom total effective rates in the treatment group were 92.9％,91.9％ and 93.9％,respectively,which were significantly higher than those in the control group (83.5％,84.5％ and 85.6％,respectively;P ＜ 0.05).CONCLUSION The curative effect of Weifuchun combined with quadruple therapy is superior to quadruple therapy in the treatment of H.pylori related chronic non-atrophic gastritis,and it can effectively improve H.pylori eradication rate.