Abstract: AIM To observe the clinical effect of integrated Chinese and Western medicine in the treatment of cerebral hemorrhage with gastrointestinal hemorrhage and its influence on prognosis.METHODS Seventy patients with cerebral hemorrhage and gastrointestinal bleeding were randomly divided into a control group (n =35) and an observation group (n =35).Both groups were treated with hemocoagulase and omeprazole injection,and the observation group was additionally given Xijiao Dihuang decoction.Clinical curative effect and prognosis were compared between the two groups.RESULTS The duration of continued bleeding and intracranial hypertension,the amount of blood transfusion,NIHSS score,survival rate,and mortality rate were significantly lower in the observation group than in the control group (t =17.935,18.293,16.386,and 20.915,x2 =5.193,7.012,P < 0.05).The hemoglobin level,MBI score,and improvement rate were significantly higher in the observation group than in the control group (t =21.284,19.841,x2 =6.395,P < 0.05).CONCLUSION Hemocoagulase and omeprazole injection combined with Xijiao Dihuang decoction are effective in the treatment of cerebral hemorrhage with gastrointestinal bleeding.