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MicroRNAs regulate hepatic fibrosis via TGF-β/Smad pathway

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Author:
No author available
Journal Title:
World Chinese Journal of Digestology
Issue:
2
DOI:
10.11569/wcjd.v25.i2.166
Key Word:
微小RNA;TGF-β/Smad;肝纤维化;MicroRNA;TGF-β/Smad;Hepatic fibrosis

Abstract´╝Ü 已有研究表明转化生长因子-β3(transforming growth factor-3,TGF-β)是最重要的促肝纤维化(hepatic fibrosis,HF)因子之一,TGF-β/Smad信号转导通路是HF主要的信号转导通路.而微小RNA(microRNA,miRNA)在HF发生过程中存在异常表达,并对HF的发生和发展有着不可忽视的作用.近年来有研究提示:通过外源性调控相关miRNA表达可能影响TGF-β/SMAD通路,从而影响HF的发生发展.文章就TGF-β3/SMAD通路及与其相关的miRNA分子与HF的关系作一综述.

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