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MicroRNAs regulate hepatic fibrosis via TGF-β/Smad pathway

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Author:: No author available

Journal Title:: World Chinese Journal of Digestology

Issue:: 2

DOI:: 10.11569/wcjd.v25.i2.166

Key Word:: 微小RNA;TGF-β/Smad;肝纤维化;MicroRNA;TGF-β/Smad;Hepatic fibrosis

Abstract：已有研究表明转化生长因子-β3(transforming growth factor-3,TGF-β)是最重要的促肝纤维化(hepatic fibrosis,HF)因子之一,TGF-β/Smad信号转导通路是HF主要的信号转导通路.而微小RNA(microRNA,miRNA)在HF发生过程中存在异常表达,并对HF的发生和发展有着不可忽视的作用.近年来有研究提示:通过外源性调控相关miRNA表达可能影响TGF-β/SMAD通路,从而影响HF的发生发展.文章就TGF-β3/SMAD通路及与其相关的miRNA分子与HF的关系作一综述.

Reference

[1]Jinghua, Du,Xuemin, Niu,Yang, Wang,etc.MiR-146a-5p suppresses activation and proliferation of hepatic stellate cells in nonalcoholic fibrosing steatohepatitis through directly targeting Wnt1 and Wnt5a.[J].2015,5.
[2]Cong, Wang,Shanghui, Guan,Fang, Liu,etc.Prognostic and diagnostic potential of miR-146a in oesophageal squamous cell carcinoma.[J].2016.
[3]Yong Han,Yueyang Bi,Haiyang Bi,etc.miR-137 suppresses the invasion and procedure of EMT of human breast cancer cell line MCF-7 through targeting CtBP1.[J].2016,29(1).
[4]Andrea, Noetel,Monika, Kwiecinski,Natalia, Elfimova,etc.microRNA are Central Players in Anti- and Profibrotic Gene Regulation during Liver Fibrosis.[J].2012,3.
[5]Le Lu,Jinlong Wang,Hongwei Lu,etc.MicroRNA-130a and -130b enhance activation of hepatic stellate cells by suppressing PPARγ expression: A rat fibrosis model study[J].2015,465(3).
[6]Jiangfeng, Hu,Chao, Chen,Qidong, Liu,etc.The role of the miR-31/FIH1 pathway in TGF-β-induced liver fibrosis.[J].2015,129.
[7]Jia, Wang,Eagle S H, Chu,Hai-Yong, Chen,etc.microRNA-29b prevents liver fibrosis by attenuating hepatic stellate cell activation and inducing apoptosis through targeting PI3K/AKT pathway.[J].2015,6.
[8]Li,T.,Mckillop,I.H.,Schrum,L.W.,etc.Inhibitory effects of microRNA 19b in hepatic stellate cell-mediated fibrogenesis[J].2012,56(1).
[9]Feng-Rui Yang,Bu-Wu Fang,Jian-Shi Lou.Effects of Fufang Biejia Ruangan Pills on hepatic fibrosis in vivo and in vitro[J].2013,(32).
[10]李俊霞,王清兰,刘成海.扶正化瘀方调节miR322/424抗肝纤维化的作用机制研究[C].2013.
[11]Jiang, Y.,Wang, C.,Li, Y. Y.,etc.Mistletoe alkaloid fractions alleviates carbon tetrachloride-induced liver fibrosis through inhibition of hepatic stellate cell activation via TGF-?Ž?2/Smad interference[J].2014,158(1).
[12]He, Xing,Xie, Jun,Zhang, Dongmei,etc.Recombinant adeno-associated virus-mediated inhibition of microRNA-21 protects mice against the lethal schistosome infection by repressing both IL-13 and transforming growth factor beta 1 pathways[J].2015,61(6).
[13]Axel M, Gressner,Ralf, Weiskirchen,Katja, Breitkopf,etc.Roles of TGF-beta in hepatic fibrosis.[J].2002,7.
[14]T J, Xing,D F, Jiang,J X, Huang,etc.Expression and clinical significance of miR-122 and miR-29 in hepatitis B virus-related liver disease.[J].2014,13(3).
[15]Pan, Qin,Cheng, Tao,Chen, Guang-Yu,etc.Changes in microRNAs associated with hepatic stellate cell activation status identify signaling pathways[J].2009,276(18).
[16]Xu-Hua, Gong,Chao, Chen,Peng, Hou,etc.Overexpression of miR-126 inhibits the activation and migration of HSCs through targeting CRK.[J].2014,33.
[17]Qin,P.,Canjie,G.,Chao,S.,etc.Integrative analysis of the transcriptome and targetome identifies the regulatory network of miR-16: An inhibitory role against the activation of hepatic stellate cells[J].2014,24(6).
[18]Xu-You, Liu,Ya-Jun, He,Qi-Hong, Yang,etc.Induction of autophagy and apoptosis by miR-148a through the sonic hedgehog signaling pathway in hepatic stellate cells.[J].2015,5.
[19]Yu, Fujun,Guo, Yong,Chen, Bicheng,etc.MicroRNA-17-5p activates hepatic stellate cells through targeting of Smad7[J].2015,95(7).
[20]Bo-Lin Chen,Jie PENG,Qing-Fu Li,etc.Exogenous bone morphogenetic protein-7 reduces hepatic fibrosis inSchistosoma japonicum-infected micevia transforming growth factor-β/Smad signaling[J].2013,(9).
[21]Sun,X.,He,Y.,Ma,T.-T.,etc.Participation of miR-200a in TGF-β1-mediated hepatic stellate cell activation[J].2014,388(1).
[22]FENG Qi,Jiang-Feng Hu,Bao-Hai Liu,etc.Mi R-9a-5p regulates proliferation and migration of hepatic stellate cells under pressure through inhibition of Sirt1[J].2015,(34).
[23]Lee, Sang Yoon,Lee, Jihyun,Lee, HyoJung,etc.MicroRNA134 Mediated Upregulation of JNK and Downregulation of NFkB Signalings Are Critically Involved in Dieckol Induced Antihepatic Fibrosis[J].2016,64(27).
[24]Chunli Liang,Shurui Bu,Xiaoming Fan.Suppressive effect of microRNA-29b on hepatic stellate cell activation and its crosstalk with TGF-β1/Smad3[J].2016,(5).
[25]Huang, C.,Lv, X.-W.,Long, X.-R.,etc.MicroRNA-146a modulates TGF-beta1-induced hepatic stellate cell proliferation by targeting SMAD4[J].2012,24(10).
[26]Tu, Xiaolong,Zheng, Xiuxiu,Li, Huanan,etc.MicroRNA-30 Protects Against Carbon Tetrachloride-induced Liver Fibrosis by Attenuating Transforming Growth Factor Beta Signaling in Hepatic Stellate Cells[J].2015,146(1).
[27]Tu,X.,Zhang,H.,Zhang,J.,etc.MicroRNA-101 suppresses liver fibrosis by targeting the TGFβ signalling pathway[J].2014,234(1).
[28]Lu, Jeng-Wei,Liao, Chung-Yi,Yang, Wan-Yu,etc.Overexpression of Endothelin 1 Triggers Hepatocarcinogenesis in Zebrafish and Promotes Cell Proliferation and Migration through the AKT Pathway.[J].2014,9(1).
[29]Benjamin P, Lewis,Christopher B, Burge,David P, Bartel.Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets.[J].2005,120(1).
[30]Zheng, Jianjian,Wu, Cunzao,Xu, Ziqiang,etc.Hepatic stellate cell is activated by microRNA-181b via PTEN/Akt pathway[J].2015,398(1).
[31]Yang, Song,Lei, Zhan,Mingzhe, Yu,etc.TRPV4 channel inhibits TGF-β1-induced proliferation of hepatic stellate cells.[J].2014,9(7).
[32]Nanzheng, Chen,Qianqian, Geng,Jianbao, Zheng,etc.Suppression of the TGF-β/Smad signaling pathway and inhibition of hepatic stellate cell proliferation play a role in the hepatoprotective effects of curcumin against alcohol-induced hepatic fibrosis.[J].2014,34.
[33]Zhiyong, Liu,Jian, Yi,Rong, Ye,etc.miR-144 regulates transforming growth factor-β1 iduced hepatic stellate cell activation in human fibrotic liver.[J].2015,8(4).
[34].miR-33a levels in hepatic and serum after chronic HBV-induced fibrosis[J].2015,50(4).
[35]Niu, Xuemin,Fu, Na,Du, Jinghua,etc.miR-1273g-3p modulates activation and apoptosis of hepatic stellate cells by directly targeting PTEN in HCV-related liver fibrosis[J].2016,590(16).
[36]Hultcrantz R,Andersson U,Kinnman N.In situ expression of transforming growth factor-beta1-3, latent transforming growth factor-beta binding protein and tumor necrosis factor-alpha in liver tissue from patients with chronic hepatitis C.[J].2000,35(12).
[37]Gao,S.,Lin,Z.,Yu,F.,etc.Activation of hepatic stellate cells is suppressed by microRNA-150[J].2013,32(1).
[38]Li D,Friedman SL.Liver fibrogenesis and the role of hepatic stellate cells: new insights and prospects for therapy.[J].1999,14(7).
[39]Yongtao Xiao,JunWang,Yingwei Chen,etc.Up-regulation of miR-200b in biliary atresia patients accelerates proliferation and migration of hepatic stallate cells by activating PI3K/Akt signaling[J].2014,26(5).