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Effect of chronic hepatitis B on liver function, serum lipids,blood glucose and insulin in patients with NAFLD

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Author:
No author available
Journal Title:
World Chinese Journal of Digestology
Issue:
23
DOI:
10.11569/wcjd.v24.i23.3523
Key Word:
慢性乙型肝炎;乙型肝炎病毒;非酒精性脂肪型肝病;Chronic viral hepatitis;Hepatitis B virus;Non-alcoholic fatty liver disease

Abstract´╝Ü 目的:非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)合并慢性乙型肝炎病毒(hepatitis B virus,HBV)患者血清中肝功能、血脂、血糖和胰岛素水平的研究.方法:收集永康市第一人民医院2014-01/2015-12收治的NAFLD86例,其中NAFLD组39例,NAFLD合并HBV感染组37例;并选择同期健康体检者38例为正常对照组.观察3组肝功能、血脂及空腹血糖、胰岛素表达水平及胰岛素抵抗指数.结果:NAFLD组及NAFLD合并HBV感染组总胆红素(total bilirubin,TBIL)、直接胆红素(direct bilirubin,DBIL)、谷丙转氨酶(alanine transaminase,ALT)、谷草转氨酶(aspartate transaminase,AST)、γ-谷氨酰转肽酶(γ-glutamyl transpeptidase,GGT)均高于正常对照组,且NAFLD合并HBV感染组TBIL、DBIL、ALT、AST、GGT均高于单纯NAFLD组,差异均具有统计学意义(P<0.05);NAFLD组及NAFLD合并HBV感染组低密度脂蛋白(low-density lipoprotein,LDL)、胆固醇(total cholesterol,TC)、三酰甘油(triacylglycerol,TG)均高于正常对照组,NAFLD合并HBV感染组LDL、TC、TG均高于单纯NAFLD组,差异均具有统计学意义(P<0.05);NAFLD组及NAFLD合并HBV感染组空腹血糖(fasting plasma glucose,FPG)、空腹胰岛素(fasting insulin,FINS)均高于正常对照组,胰岛素抵抗指数胰岛素敏感指数(insulin sensitivity index,ISI)低于单纯NAFLD组,且NAFLD合并HBV感染组FPG、FINS高于单纯NAFLD组,胰岛素抵抗指数ISI低于单纯NAFLD组(P0.05).结论:NAFLD患者感染慢性HBV后,胰岛素敏感性降低,体内代谢紊乱加重,肝脏损伤进一步加剧.

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