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Roles and mechanisms of action of microRNAs in colorectal cancer

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Author:: No author available

Journal Title:: World Chinese Journal of Digestology

Issue:: 22

DOI:: 10.11569/wcjd.v24.i22.3362

Key Word:: MicroRNAs;结直肠癌;信号通路;早期诊断;预后评估;MicroRNAs;Colorectal cancer;Signal pathway;Early diagnosis;Prognosis evaluation

Abstract： MicroRNAs(miRNAs)是一类进化高度保守的内源性、小分子非编码RNA,其异常表达时不仅可以通过调控DNA甲基化或诱导肿瘤微环境的改变,也可以直接或间接的作用Wnt/β-catenin、PI3K、K-RAS和上皮-间质转化(epithelial mesenchymal transitions,EMT)等信号调节通路的相关靶点,在各类肿瘤的发生、发展、转移以及复发中起着至关重要的作用.近年来研究发现,许多miRNAs在结直肠癌中异常表达,并且参与和调控了结直肠癌形成和发展的各个阶段.因而深入研究miRNAs在结直肠癌中的作用及其机制,有望在结直肠癌的早期诊断、临床分期、治疗以及预后评估等方面提供一系列崭新的思路.

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