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Correlation of plasma lipid levels with serum hepatitis C virus RNA load and liver histopathological changes in patients with chronic hepatitis C
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- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 17
- DOI:
- 10.3969/j.issn.1009-3079.2010.17.014
- Key Word:
- 丙型肝炎病毒;慢性丙型肝炎;脂类;代谢;组织病理学
Abstract： 目的:探讨慢性丙型肝炎患者脂类代谢与病毒复制状态以及肝脏病理损伤程度的关系.方法:以75例慢性丙型肝炎(CHC)患者为研究对象,应用FQ-PCR方法检查患者血清HCVRNA载量;应用全自动生物化学分析仪检测患者外周血三酰甘油(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、载脂蛋白A(ApoA)、载脂蛋白B(ApoB)水平;肝脏病理行HE染色,对炎症、纤维化和脂肪变进行分级.分析脂类代谢指标和HCVRNA载量、肝功能指标以及肝脏病理分级的关系.结果:不同HCV复制状态的CHC患者之间的血浆TG、CHO、HDL、ApoA水平的差异无显著性,但血浆LDL、ApoB水平在三组间比较差异有显著性(P=0.037和0.027),表现为HCVRNA载量越高,LDL和ApoB水平越低;相关分析显示HCVRNA载量和LDL、ApoB之间呈负相关(r=-0.305,-0.417,P=0.011,0.001);67.7%CHC患者有不同程度的肝脂肪变性,不同程度肝脂肪变的CHC患者之间只有HCVRNA载量有显著性差异,肝脂肪变越高,HCVRNA载量越高,其他指标在各组间差异无显著性.结论:外周血LDL、ApoB水平和肝脂肪变程度与HCV复制密切相关,但未发现与肝脏损伤程度和肝纤维程度相关性.
- [1]中华医学会肝病学分会.丙型肝炎防治指南[J].2004,(7).
- [2]Serfaty L,Poupon R,Giral P,etc.Hepatitis C virus induced hypobetalipoproteinemia: a possible mechanism for steatosis in chronic hepatitis C.[J].2001,34(3).
- [3].病毒性肝炎防治方案[J].2000,(6).
- [4]Negro F,Sanyal AJ.Hepatitis C virus, steatosis and lipid abnormalities: clinical and pathogenic data.[J].2009,29(Suppl.2).
- [5]Corey KE,Munroe C,Kane E.Hepatitis C virus infection and its clearance alter circulating lipids: implications for long-term follow-up.[J].2009,50(4).
- [6]Fernandez-Rodriguez CM,Romero-Gomez M,Andrade RJ,etc.Effect of sustained virological response to treatment on the incidence of abnormal glucose values in chronic hepatitis C.[J].2008,48(5).
- [7]Venugopal S,Vu K,Murthy GD.Prevalence and treatment of hyperlipidemia in patients with chronic hepatitis C infection.[J].2009,21(8).
- [8]Agata Budkowska,Michela E. Burlone.Hepatitis C virus cell entry: role of lipoproteins andcellular receptors[J].2009,90(5).
- [9]Tsutsumi T,Miyoshi H,Moriya K.Tacrolimus ameliorates metabolic disturbance and oxidative stress caused by hepatitis C virus core protein: analysis using mouse model and cultured cells.[J].2009,175(4).
- [10]Thomssen R,Kippenberger S,Muller A,etc.Binding of human lipoproteins (low, very low, high density lipoproteins) to recombinant envelope proteins of hepatitis C virus.[J].2000,188(4).