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Advances in research on the mechanisms of tamoxifen therapy for cholangiocarcinoma
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- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 4
- DOI:
- 10.3969/j.issn.1009-3079.2010.04.010
- Key Word:
- 胆管癌;三苯氧胺;抗雌激素;肿瘤
Abstract： 胆管癌(cholangiocarcinoma,CCA)是一种来源于肝内或肝外胆管上皮细胞的恶性肿瘤.早期诊断困难,临床疗效差和5年生存率低等特点使之成为临床重点攻坚肿瘤.因此,需要研究和开发新型有效的化疗药物.三苯氧胺(tamoxifen,TAM)是一种非甾体类抗雌激素药物,临床上主要用于乳腺癌的治疗,对其他肿瘤包括CCA也有抑制活性,但具体机制尚不完全清楚.本文主要阐述TAM抗CCA机制的研究进展.
- [1]Nisana Tepsiri,Liengchai Chaturat,Banchob Sripa,etc.Drug sensitivity and drug resistance profiles of human intrahepatic cholangiocarcinoma cell lines[J].2005,(18).
- [2]雷元卫,陈廷暄.胆管癌性激素受体的表达及其临床病理学意义[J].2004,(3).
- [3]刘伟,安杰,崔忠,等.胆管癌组织中MRP1/GST-π的表达及临床意义[J].2009,(8).
- [4]王宝成,李志,毕经旺,等.大剂量他莫昔芬逆转晚期结肠癌多药耐药性的临床研究[J].2005,(21).
- [5]范正军,吴阳,王志军.雌、孕激素受体在肝门部胆管癌中的表达及意义[J].2005,(37).
- [6]O. M. Taylor,E. A. Benson,M. J. McMahon.Clinical trial of tamoxifen in patients with irresectable pancreatic adenocarcinoma[J].1993,80(3).
- [7]Yoshimitsu Naniwa,Tsuyoshi Hayashi,Atsushi Nobuoka,etc.Reversal of Multiple Drug Resistance in Cholangiocarcinoma by the Glutathione S-Transferase-pi-Specific Inhibitor O~1-Hexadecyl-gamma-glutamyl-S-benzylcysteinyl-D-phenylglycine Ethylester[J].2003,306(3).
- [8]Liu, Zhi-Hua,Qin, Huanlong,He, Yan-Ping.The growth-inhibition effect of tamoxifen in the combination chemotherapeutics on the human cholangiocarcinoma cell line QBC939[J].2010,37(6).
- [9]S, Mandlekar,A N, Kong.Mechanisms of tamoxifen-induced apoptosis.[J].2001,6(6).
- [10]Ding Haitao,Chen Yabing,McDonald Jay M.,etc.Calmodulin binding to cellular FLICE-like inhibitory protein modulates Fas-induced signalling[J].2008,412(3).
- [11]Pawar P,Byon CH,Liu H,etc.Molecular mechanisms of tamoxifen therapy for cholangiocarcinoma: role of calmodulin.[J].2009,15(4).
- [12]S, DeMorrow.Cholangiocarcinoma: estrogen-induced autocrine effects of VEGF on cell proliferation.[J].2009,41(2).
- [13]Elliott P,Beck A,Thomas HC,etc.Changing international trends in mortality rates for liver, biliary and pancreatic tumours.[J].2002,37(6).
- [14]Shaib Y,El Serag HB.The epidemiology of cholangiocarcinoma.[J].2004,24(2).
- [15]Nakamura T,Ajiki T,Kamigaki T,etc.High expression of thymidylate synthase leads to resistance to 5-fluorouracil in biliary tract carcinoma in vitro.[J].2001,92(10).
- [16]Galligan L,Longley DB,Thomas M,etc.Cellular FLICE-inhibitory protein regulates chemotherapy-induced apoptosis in breast cancer cells.[J].2007,6(5).
- [17]Alpini G,Bolognese A,Francis H,etc.Estrogens stimulate the proliferation of human cholangiocarcinoma by inducing the expression and secretion of vascular endothelial growth factor.[J].2009,41(2).
- [18]Anderson CD,Berlin J,Chari RS,etc.Diagnosis and treatment of cholangiocarcinoma.[J].2004,9(1).
- [19]Domenico Alvaro,Maria Grazia Mancino,Paolo Onori,etc.Estrogens and the pathophysiology of the biliary tree[J].2006,(22).
- [20]Wongkham S,Junking M,Wongkham C.Suppression of galectin-3 expression enhances apoptosis and chemosensitivity in liver fluke-associated cholangiocarcinoma.[J].2009,100(11).
- [21]E P, Gelmann.Tamoxifen for the treatment of malignancies other than breast and endometrial carcinoma.[J].1997,24.
- [22]Mano T,Suhara T,Walsh K,etc.Phosphatidylinositol 3-kinase/Akt activity regulates c-FLIP expression in tumor cells.[J].2001,276(10).
- [23]L K, Sampson,S M, Vickers,W, Ying,etc.Tamoxifen-mediated growth inhibition of human cholangiocarcinoma.[J].1997,57.
- [24]Han P,Li HL,Kang JH.Antiproliferation and apoptosis induced by tamoxifen in human bile duct carcinoma QBC939 cells via upregulated p53 expression.[J].2009,385(2).
- [25]Ahn EY,Lim ST,McDonald JM,etc.Calmodulin binding to the Fas death domain. Regulation by Fas activation.[J].2004,279(7).
- [26]Holscher M,Schmitz KJ,Levkau B,etc.Prognostic relevance of activated Akt kinase in node-negative breast cancer: a clinicopathological study of 99 cases.[J].2004,17(1).
- [27]Dong B,Valencia CA,Liu R.Ca(2+)/calmodulin directly interacts with the pleckstrin homology domain of AKT1.[J].2007,282(34).