You Position: Home > Paper
Effects of IFNα-2a on bcl-2 expression in the fibrotic liver of rats
( views:165, downloads:8 )
- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 31
- DOI:
- 10.3969/j.issn.1009-3079.2009.31.011
- Key Word:
- 肝纤维化;α-2a干扰素;bcl-2基因
Abstract： 目的:探讨α-2a干扰素(IFNα-2a)对大鼠肝组织bcl-2基因表达的影响和对肝纤维化的作用及其机制.方法:将SD大鼠随机分成纤维化模型组(A组,CCl4诱导形成大鼠肝纤维化模型),对照组(B组)及IFNα-2a干预组(C组).用RT-PCR法检测各组大鼠肝脏bcl-2的表达,常规HE和网状纤维染色检测肝组织标本.结果:C组纤维化程度及肝细胞脂肪变性较A组显著减轻,但肝组织炎症改变无显著差异性.C组bcl-2基因蛋白表达显著低于A组(P<0.01),但显著高于B组bcl-2基因蛋白表达的量(P<0.01).结论:IFNα-2a能够阻断CCl4诱导的肝纤维化和减少肝脂肪变性.其机制与bcl-2基因表达有关,可能通过调节bcl-2基因表达与HSC凋亡,从而阻断肝纤维化和减少肝脂肪变性.
- [1]Sobaniec-Lotowska Maria Elzbieta,Lebensztejn Dariusz Marek.Histological outcome of chronic hepatitis B in children treated with interferon alpha[J].2005,(45).
- [2]李继强,柳怿,刘文忠,等.依那普利对肝组织bax和bcl-2基因表达的影响[J].2006,(8).
- [3]Bataller R,Brenner DA.Liver fibrosis.[J].2005,115(2).
- [4]Nagano H,Seo Y,Yano Y,etc.Significance of serum matrix metalloproteinases and their inhibitors onthe antifibrogenetic effect of interferon-alfa in chronic hepatitis Cpatients[J].2001,44(4).
- [5]李石.肝纤维化发生机制[J].1999,(1).
- [6]王丽辉,童坦君.神经生长因子[J].1992,(1).
- [7]Friedman SL.Mechanisms of disease: Mechanisms of hepatic fibrosis and therapeutic implications.[J].2004,1(2).
- [8]Ping J,Xu LM,Cheng Y.Effects of curcumin on peroxisome proliferator-activated receptor gamma expression and nuclear translocation/redistribution in culture-activated rat hepatic stellate cells.[J].2007,120(9).
- [9]R, Brenard.Practical management of patients treated with alpha interferon.[J].1900,60.
- [10]Watanabe T,Arai M,Maruyama K,etc.Dynamic change of cells expressing MMP-2 mRNA and MT1-MMP mRNA in the recovery from liver fibrosis in the rat.[J].2001,35(4).