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Expression of cluster of differentiation antigen-14 in intestinal mucosa of patients with inflammatory bowel disease and its implication
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- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 24
- DOI:
- 10.3969/j.issn.1009-3079.2009.24.019
- Key Word:
- CD14;溃疡性结肠炎;克罗恩病
Abstract： 目的: 探讨炎症性肠病患者肠黏膜CD14的表达及与该病的关系.方法: 收集活动性溃疡性结肠炎(ulcerative colitis, UC)患者25例及克罗恩病(Crohn's disease, CD)患者15例;20例对照来自于非炎症性肠病患者手术切除的正常结肠组织(肠镜及肠黏膜病理组织学检查结果均正常).炎症性肠病的临床诊断均依据于常规影像学、内镜学及组织学标准.采用免疫组织化学方法检测肠黏膜组织中CD14表达量.结果: 肠黏膜固有层单个核细胞表达CD14.UC患者CD14阳性细胞百分数高于CD患者,但二者差异无统计学意义(P>0.05);UC患者较正常对照有显著性差异(t=4.404, P<0.01),CD患者较正常对照亦见显著性差异(t=3.324,P<0.01).CD14的表达与疾病活动度(diseaseactivity index, DAI)相关, UC组轻、中、重度比较有显著性差异(F=56.709, P<0.01);CD组轻、中、重度比较亦有显著性差异(F=12.880, P<0.01).结论: CD14参与了炎症性肠病的发病过程, 其表达强度反映了该病的程度.
- [1]David Q Shih,Stephan R Targan.Immunopathogenesis of inflammatory bowel disease[J].2008,(3).
- [2]冉志华,沈骏.炎症性肠病治疗中的新概念[J].2009,(2).
- [3]中华医学会消化病学分会炎症性肠病协作组.对我国炎症性肠病诊断治疗规范的共识意见（2007年，济南）[J].2007,(8).
- [4]张葵.CD14的研究进展及临床意义[J].2003,(6).
- [5]J Rugtveit,EM Nilsen,A Bakka,etc.Cytokine profiles differ in newly recruited and resident subsets of mucosal macrophages from inflammatory bowel disease[J].1997,112(5).
- [6]Le Roy-D,Lengacher S,Heumann D,etc.Monoclonal antibodies to murine lipopolysaccharide (LPS)-binding protein (LBP) protect mice from lethal endotoxemia by blocking either the binding of LPS to LBP or the presentation of LPS/LBP complexes to CD14.[J].1999,162(12).
- [7]M. C. GRIMM,P. PAVLI,E. VAN DE POL,etc.Evidence for a CD14+ population of monocytes in inflammatory bowel disease mucosa-implications for pathogenesis[J].1995,100(2).
- [8]Ulevitch RJ,Gegner JA,Tobias PS.Lipopolysaccharide (LPS) signal transduction and clearance. Dual roles for LPS binding protein and membrane CD14.[J].1995,270(10).
- [9]Drastich P,Klimesova K,Rossmann P,etc.Expression of Toll-like Receptor 2 (TLR2), TLR4, and CD14 in Biopsy Samples of Patients With Inflammatory Bowel Diseases: Upregulated Expression of TLR2 in Terminal Ileum of Patients With Ulcerative Colitis.[J].2008,56(3).
- [10]Daniele Fina,Roberta Caruso,Giovanni Monteleone,etc.Interleukin-21 (IL-21) Controls Inflammatory Pathways in the Gut[J].2007,7(4).